Evidence map›Paper›PMID 34397126›Full record

ArticleJournal of paediatrics and child health2022

Sleep-disordered breathing in Australian children with Prader-Willi syndrome following initiation of growth hormone therapy.

Daan Caudri, Gillian M Nixon, Aleisha Nielsen, Linda Mai, Claire R Hafekost, Nitin Kapur, Chris Seton, Andrew Tai, Greg Blecher, Geoff Ambler and 11 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of paediatrics and child health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Long-term effect of growth hormone on sleep-disordered breathing in Malaysian children with Prader-Willi syndrome: a retrospective study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  9. Review
  10. Review
  11. Review
  12. Sleep Consequences of Prader-Willi Syndrome.Current neurology and neuroscience reports · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 2 countries.

Daan CaudriTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-8191-8598
Gillian M NixonMelbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, Victoria, Australia.
Aleisha NielsenRespiratory and Sleep Medicine, Perth Children's Hospital, Perth, Western Australia, Australia.
Linda MaiFaculty of Medicine and Health Sciences, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-1968-3481
Claire R HafekostTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Nitin KapurRespiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.
Chris SetonDepartment of Sleep Medicine, Children's Hospital Westmead, Sydney, New South Wales, Australia.
Andrew TaiRespiratory and Sleep Department, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Greg BlecherDepartment of Sleep Medicine, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Geoff AmblerThe Sydney Children's Hospitals Network, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0003-0579-3452
Philip B BergmanDepartment of Paediatrics, Monash University, Melbourne, Victoria, Australia.
Komal A VoraDepartment of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, New South Wales, Australia.ORCID https://orcid.org/0000-0003-2487-3319
Patricia CrockDepartment of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, New South Wales, Australia.
Charles F VergeDepartment of Endocrinology, Sydney Children's Hospital, Randwick, New South Wales, Australia.
Elaine ThamEndocrinology and Diabetes Department, Women's and Children's Hospital, Adelaide, South Australia, Australia.
Yassmin MusthaffaSchool of Clinical Medicine, University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-9971-7084
Antony R LaffertyDepartment of Endocrinology and Diabetes, Canberra Hospital, Garran, Australian Capital Territory, Australia.
Peter JacobyTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Andrew C WilsonTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Jenny DownsTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-7358-9037
Catherine S ChoongTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
The Kids Research Institute Australia · AUJohn Hunter Children's Hospital · AUMonash Children’s Hospital · AUThe University of Queensland · AUThe University of Sydney · AUWomen's and Children's Hospital · AUAustralian National University · AUPrincess Margaret Hospital for Children · AUSydney Children's Hospital · AUThe University of Western Australia · AUUNSW Sydney · AU

Funding

Perth Children's Hospital Foundation 2016 Grant to D Caudri, 2018 Grant to CS Choong, J Downs, D Caudri, H LeonPrader-Willi Association USA 2016 Research Grant to CS Choong, D Caudri and A Wilson
6 · The paper itself

Abstract

aimIn children with Prader-Willi syndrome (PWS), growth hormone (GH) improves height and body composition; however, may be associated with worsening sleep-disordered breathing (SDB). Some studies have reported less SDB after GH initiation, but follow-up with polysomnography is still advised in most clinical guidelines.

methodsThis retrospective, multicentre study, included children with PWS treated with GH at seven PWS treatment centres in Australia over the last 18 years. A paired analysis comparing polysomnographic measures of central and obstructive SDB in the same child, before and after GH initiation was performed with Wilcoxon signed-rank test. The proportion of children who developed moderate/severe obstructive sleep apnoea (OSA) was calculated with their binomial confidence intervals.

resultsWe included 112 patients with available paired data. The median age at start of GH was 1.9 years (range 0.1-13.5 years). Median obstructive apnoea hypopnoea index (AHI) at baseline was 0.43/h (range 0-32.9); 35% had an obstructive AHI above 1.0/h. Follow-up polysomnography within 2 years after the start of GH was available in 94 children who did not receive OSA treatment. After GH initiation, there was no change in central AHI. The median obstructive AHI did not increase significantly (P = 0.13), but 12 children (13%, CI

conclusionsOur findings of a worsening of OSA severity in 13% of children with PWS support current advice to perform polysomnography after GH initiation. Early identification of worsening OSA may prevent severe sequelae in a subgroup of children.

Indexed as

Prader-Willi SyndromeSleep Apnea SyndromesAdolescentAustraliaChildChild, PreschoolGrowth HormoneHumansInfantRetrospective StudiesGrowth Hormonecentral sleep apnoeagrowth hormoneobstructive sleep apnoeapolysomnographyPrader-Willi syndromesleep-disordered breathing

Identifiers

PMID34397126
PMCPMC9290886
OpenAlexW3195250471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.