Evidence map›Paper›PMID 34397083›Full record

Observational studyThe Journal of clinical endocrinology and metabolism2022

Low Adrenomedullary Function Predicts Acute Illness in Infants With Classical Congenital Adrenal Hyperplasia.

Jonathan Weber, Veeraya K Tanawattanacharoen, Amy Seagroves, Mark C Liang, Christina M Koppin, Heather M Ross, Tania A S S Bachega, Mitchell E Geffner, Monica Serrano-Gonzalez, Gagandeep Bhullar and 1 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Screening for Anxiety and Depression in Children with Congenital Adrenal HyperplasiaJournal of clinical research in pediatric endocrinology · 2023
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jonathan WeberCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Veeraya K TanawattanacharoenCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Amy SeagrovesCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Mark C LiangCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Christina M KoppinCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Heather M RossCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Tania A S S BachegaLaboratory of Hormones and Molecular Genetics-LIM 42, Division of Endocrinology, Clinics Hospital, School of Medicine, São Paulo University, São Paulo 05508-220, Brazil.
Mitchell E GeffnerCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Monica Serrano-GonzalezKeck School of Medicine of University of Southern California, Los Angeles, California 90033, USA.
Gagandeep BhullarCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Mimi S KimCenter for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.ORCID 0000-0002-6266-3569
Children's Hospital of Los Angeles · USUniversity of Southern California · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Brain and Adipose Contributors to Food Seeking in Youth with Adrenal HyperplasiaK23HD084735 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, MIMI SUSAN · 2016 to 2018
$474k
Effects of Androgen Excess on Lipid Distribution in Congenital Adrenal HyperplasiaR03HD101718 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, MIMI SUSAN · 2020 to 2021
$183k
NCATS NIH HHS KL2 TR001854NCATS NIH HHS UL1 TR001855NICHD NIH HHS K23 HD084735NICHD NIH HHS R03 HD101718NIH HHS 1K23HD084735-01A1
6 · The paper itself

Abstract

contextYouth with classical congenital adrenal hyperplasia (CAH) exhibit abnormal adrenomedullary function with decreased epinephrine levels noted in newborns and young infants. Little is known about how this relates to morbidity during the first year of life.

objectiveThis work aimed to study plasma epinephrine levels in infants with classical CAH and examine the clinical significance of epinephrine deficiency in the first year of life.

methodsThis prospective cohort study comprised participants recruited from a pediatric tertiary care center: 36 infants with classical CAH due to 21-hydroxylase deficiency and 27 age-matched unaffected controls with congenital hypothyroidism. Main outcome measures included plasma epinephrine levels (N = 27), CYP21A2 genotype (N = 15), and incidence of acute illnesses from birth to age 1 year (N = 28).

resultsEpinephrine levels in CAH infants independently predicted illness incidence in the first year of life (β = -0.018, R = -0.45, P = .02) and were negatively correlated with 17-hydroxyprogesterone at diagnosis (R = -0.51, P = .007). Infants with salt-wasting CAH exhibited lower epinephrine levels as newborns than simple-virilizing infants (P = .02). CAH patients had lower epinephrine as newborns than did controls (P = .007) and showed decreases in epinephrine from birth to age 1 year (P = .04). Null genotype was associated with lower newborn epinephrine and more illness in the first year of life, compared to less severe mutation categories.

conclusionLower epinephrine levels are associated with increased risk of illness among CAH infants. While not currently part of clinical standard of care, measuring epinephrine levels and assessing genotype may help predict acute illness in the first year of life.

Indexed as

Acute DiseaseAdrenal Hyperplasia, CongenitalAdrenal MedullaCase-Control StudiesCongenital HypothyroidismEpinephrineFemaleHumansIncidenceInfantInfant, NewbornMaleMutationProspective StudiesRisk AssessmentSteroid 21-HydroxylaseCYP21A2 protein, humanEpinephrineSteroid 21-Hydroxylaseadrenal medullacatecholaminescongenital adrenal hyperplasiaepinephrineillnesspediatrics

Identifiers

PMID34397083
PMCPMC8826013
OpenAlexW3194969207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.