Evidence map›Paper›PMID 34396800›Full record

Observational studyJournal of diabetes science and technology2022

Acute and Chronic Glucose Control in Critically Ill Patients With Diabetes: The Impact of Prior Insulin Treatment.

James S Krinsley, Peter Rule, Michael Brownlee, Gregory Roberts, Jean-Charles Preiser, Sherose Chaudry, Krista Dionne, Camilla Heluey-Rodrigues, Guillermo E Umpierrez, Irl B Hirsch

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

James S KrinsleyDivision of Critical Care, Department of Medicine, Stamford Hospital, and the Columbia Vagelos College of Physicians and Surgeons, Stamford, CT, USA.ORCID 0000-0002-3763-5857
Peter RulePRI, Los Altos Hills, CA, USA.
Michael BrownleeEinstein Diabetes Research Center, Professor of Medicine and Pathology Emeritus, Albert Einstein College of Medicine, Bronx, NY, USA.
Gregory RobertsFlinders Medical Centre, Bedford Park, SA, Australia.
Jean-Charles PreiserErasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Sherose ChaudryDivision of Critical Care, Department of Medicine, Stamford Hospital, and the Columbia Vagelos College of Physicians and Surgeons, Stamford, CT, USA.
Krista DionneDivision of Critical Care, Department of Medicine, Stamford Hospital, and the Columbia Vagelos College of Physicians and Surgeons, Stamford, CT, USA.
Camilla Heluey-RodriguesDivision of Critical Care, Department of Medicine, Stamford Hospital, and the Columbia Vagelos College of Physicians and Surgeons, Stamford, CT, USA.
Guillermo E UmpierrezDivision of Endocrinology, Emory University School of Medicine, Atlanta GA, USA.ORCID 0000-0002-3252-5026
Irl B HirschUniversity of Washington Medicine Diabetes Institute, Seattle, WA, USA.
Stamford Hospital · USAlbert Einstein College of Medicine · USEmory University · USFlinders Medical Centre · AUUniversité Libre de Bruxelles · BEUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging data highlight the interactions of preadmission glycemia, reflected by admission HbA1c levels, glycemic control during critical illness, and mortality. The association of preadmission insulin treatment with outcomes is unknown.

methodsThis observational cohort study includes 5245 patients admitted to the medical-surgical intensive care unit of a university-affiliated teaching hospital. Three groups were analyzed: patients with diabetes with prior insulin treatment (DM-INS,

resultsAmong the three strata of HbA1c, mean blood glucose (BG), coefficient of variation (CV), and hypoglycemia increased with increasing HbA1c, and were higher for DM-INS than for DM-No-INS. Among patients with HbA1c < 6.5%, mean BG ≥ 180 mg/dL and CV > 30% were associated with lower severity-adjusted mortality in DM-INS compared to patients with mean BG 80-140 mg/dL and CV < 15%, (

conclusionsSignificant differences in mortality were found among patients with diabetes based on insulin treatment and HbA1c at home and post-admission glycemic control. Prospective studies need to confirm an individualized approach to glycemic control in the critically ill.

Indexed as

Critical IllnessDiabetes MellitusBlood GlucoseGlycated HemoglobinHumansInsulinProspective StudiesRetrospective StudiesBlood GlucoseGlycated HemoglobinInsulincritically illdiabetesHbA1chypoglycemiainsulinmortality

Identifiers

PMID34396800
PMCPMC9631540
OpenAlexW3195895609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.