Evidence map›Paper›PMID 34396788›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts.

Nancy S Krieger, David A Bushinsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nancy S KriegerDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York.ORCID 0000-0001-5980-5127
David A BushinskyDivision of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York.
University of Rochester · US

Funding

Hypercalciuria and Bone Quality in the Genetic Hypercalciuric Stone-Forming RatsR01DK075462 · NIDDK · UNIVERSITY OF ROCHESTER · PI BUSHINSKY, DAVID A · 2008 to 2019
$3.8M
EFFECTS OF ACID ON BONER01AR046289 · NIAMS · UNIVERSITY OF ROCHESTER · PI BUSHINSKY, DAVID A · 2000 to 2010
$3.0M
HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) AR-46289HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) DK 075462NIAMS NIH HHS R01 AR046289NIDDK NIH HHS R01 DK075462
6 · The paper itself

Abstract

Chronic metabolic acidosis stimulates cell-mediated net Ca

Indexed as

AcidosisAnimalsBicarbonatesCarbon DioxideCells, CulturedGene Expression RegulationGTP-Binding ProteinsHydrogen-Ion ConcentrationMiceOsteoblastsRGS ProteinsRNAXanthenesBicarbonatesCarbon DioxidegalleinGTP-Binding ProteinsRGS16 proteinRGS ProteinsRNAXanthenesgalleinG protein-coupled receptormetabolic acidosisosteoblastregulator of G protein signaling 16

Identifiers

PMID34396788
PMCPMC8560403
OpenAlexW3195670642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.