Evidence map›Paper›PMID 34396715›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Nutrient Element Decorated Polyetheretherketone Implants Steer Mitochondrial Dynamics for Boosted Diabetic Osseointegration.

Hao Wang, Xinliang Fu, Jiacheng Shi, Limei Li, Jiyu Sun, Xidan Zhang, Qiuyang Han, Yi Deng, Xueqi Gan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Hao WangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xinliang FuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Jiacheng ShiSchool of Chemical Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Limei LiScience and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, China.
Jiyu SunState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xidan ZhangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Qiuyang HanSchool of Chemical Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Yi DengSchool of Chemical Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.ORCID 0000-0002-1765-5244
Xueqi GanState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Sichuan University · CNKunming Medical University · CN

Funding

Chengdu International Science and Technology Cooperation Foundation 2017-GH02-00025-HZChengdu International Science and Technology Cooperation Foundation 2020-GH03-00005-HZNational Natural Science Foundation of China 81801848National Natural Science Foundation of China 81870802National Natural Science Foundation of China 81961160736Sichuan Science and Technology Program 2018JZ0026Sichuan Science and Technology Program 2019YFS0356Sichuan Science and Technology Program 2019YJ0141Sichuan Science and Technology Program 2021YJ0049Sichuan University-Luzhou City Special Funding for Strategic Cooperation 2020CDLZ-5Sichuan University Postodoctoral Interdisciplinary InnovationState Key Laboratory of Polymer Materials Engineering sklpme2019-2-05Young Elite Scientist Sponsorship Program by CASTYouth Science and Technology Academic Leader Training Program
6 · The paper itself

Abstract

As a chronic metabolic disease, diabetes mellitus (DM) creates a hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because of mitochondrial dysfunction in hyperglycemia. To address the daunting issue, the authors innovatively devised and developed mitochondria-targeted orthopedic implants consisted of nutrient element coatings and polyetheretherketone (PEEK). Dual nutrient elements, in the modality of ZnO and Sr(OH)

Indexed as

Prostheses and ImplantsAnimalsBenzophenonesDiabetes MellitusDisease Models, AnimalFemurHumansHyperglycemiaMembrane Potential, MitochondrialMitochondriaMitochondrial DynamicsNutrientsOsseointegrationOsteoblastsOsteogenesisPolyethylene GlycolsBenzophenonesNutrientspolyetheretherketonePolyethylene GlycolsPolymersReactive Oxygen SpeciesZinc Oxidemitochondrial dynamicsnutrient elementorthopedic implantosseointegrationpolyetheretherketone

Identifiers

PMID34396715
PMCPMC8529468
OpenAlexW3194938994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.