ArticleThe EMBO journal2021
Desensitisation of Notch signalling through dynamic adaptation in the nucleus.
Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Notch Signalling Plays a Role in Patterning the Ventral Mesoderm During Early Embryogenesis inInternational journal of molecular sciences · 2026Article
- Engineering development: From the repressilator and toggle switch to synthetic developmental biology.Developmental biology · 2025Review
- Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025Review
- Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems.Seminars in cell & developmental biology · 2023Review
- Requirements for mammalian promoters to decode transcription factor dynamics.Nucleic acids research · 2023Article
- Analysis of Slow-Cycling Variants of the Light-Inducible Nuclear Protein Export System LEXY in Mammalian Cells.ACS synthetic biology · 2022Article
- Design and engineering of light-sensitive protein switches.Current opinion in structural biology · 2022Review
- Optogenetic control of NOTCH1 signaling.Cell communication and signaling : CCS · 2022Article
- Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation.eLife · 2022Article
- Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation.Cell reports · 2022Article
- [Inhibition of the Notch1/Jagged1 pathway promotes homing of bone mesenchymal stem cells to improve asthma in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Desensitisation of Notch signalling through dynamic adaptation in the nucleus.The EMBO journal · 2021Article
- A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activatingNeuro-oncology advancesArticle
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Authors and funding
4 authors.
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Abstract
During embryonic development, signalling pathways orchestrate organogenesis by controlling tissue-specific gene expression programmes and differentiation. Although the molecular components of many common developmental signalling systems are known, our current understanding of how signalling inputs are translated into gene expression outputs in real-time is limited. Here we employ optogenetics to control the activation of Notch signalling during Drosophila embryogenesis with minute accuracy and follow target gene expression by quantitative live imaging. Light-induced nuclear translocation of the Notch Intracellular Domain (NICD) causes a rapid activation of target mRNA expression. However, target gene transcription gradually decays over time despite continuous photo-activation and nuclear NICD accumulation, indicating dynamic adaptation to the signalling input. Using mathematical modelling and molecular perturbations, we show that this adaptive transcriptional response fits to known motifs capable of generating near-perfect adaptation and can be best explained by state-dependent inactivation at the target cis-regulatory region. Taken together, our results reveal dynamic nuclear adaptation as a novel mechanism controlling Notch signalling output during tissue differentiation.
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