ArticleMolecular medicine reports2021
miR‑125a‑5p and miR‑7 inhibits the proliferation, migration and invasion of vascular smooth muscle cell by targeting EGFR.
Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- MicroRNA-125a-5p promotes NLRP3/caspase-1/GSDMD pathway-mediated pyroptosis in endothelial cells during Kawasaki disease.Scientific reports · 2026Article
- Establishment of a placental lncRNA-mRNA expression network for early-onset preeclampsia.BMC pregnancy and childbirth · 2024Article
- The Role of microRNAs in Inflammation.International journal of molecular sciences · 2022Review
- DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous HAging and disease · 2022Article
- Article
- MiR-125 Family in Cardiovascular and Cerebrovascular Diseases.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ectopic proliferation, migration and invasion of vascular smooth muscle cells (VSMCs) contributes to the progression of various human vascular diseases. Accumulating evidence has demonstrated that microRNAs (miRs) exert vital functions in the proliferation and invasion of VSMCs. The current study aimed to elucidate the functions of miR‑125a‑5p and miR‑7 in VSMCs and investigate the associated molecular mechanisms. The results of EdU and reverse transcription‑quantitative PCR assays revealed that platelet‑derived growth factor (PDGF)‑BB enhanced the proliferation of VSMCs and significantly reduced the expression of miR‑125a‑5p and miR‑7. miR‑125a‑5p or miR‑7 overexpression significantly ameliorated PDGF‑BB‑induced proliferation, migration and invasion of VSMCs. Furthermore, the results demonstrated that epidermal growth factor receptor (EGFR) may be a target mRNA of miR‑125a‑5p and miR‑7 in VSMCs. The results of western blot analysis indicated that co‑transfection of miR‑125a‑5p mimics or miR‑7 mimics distinctly decreased the protein expression of EGFR in EGFR‑overexpressed VSMCs. Moreover, rescue experiments indicated that EGFR overexpression alleviated the suppressive impact of the miR‑125a‑5p and miR‑7 s on the growth, migration and invasion of VSMCs. In conclusion, the current study identified that miR‑125a‑5p and miR‑7 repressed the growth, migration and invasion of PDGF‑BB‑stimulated VSMCs by, at least partially, targeting EGFR. The current study verified that miR‑125a‑5p and miR‑7 may be used as feasible therapeutic targets for cardiovascular diseases.
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Registered trials
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