ArticleThe Journal of infectious diseases2021
Tumor Necrosis Factor Alpha-Induced Interleukin-1 Alpha Synthesis and Cell Death Is Increased in Mouse Epithelial Cells Infected With Chlamydia muridarum.
Uma M Nagarajan, Crescentia Cho, Clare E Gyorke, Shanmugam Nagarajan, J Ashley Ezzell, Hayden Brochu, Ian Huntress, Erin Harrell, Xinxia Peng
Open access · greenAbstract read
In one paragraphArticle in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors at 2 institutions in 1 country.
Uma M NagarajanDepartment of Pediatrics, University of North Carolina, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-2164-9338 Crescentia ChoDepartment of Pediatrics, University of North Carolina, University of North Carolina, Chapel Hill, North Carolina, USA.
Clare E GyorkeDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Shanmugam NagarajanDepartment of Pathology and Labortaory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
J Ashley EzzellDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Hayden BrochuDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Ian HuntressDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Erin HarrellDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
Xinxia PengDepartment of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
University of North Carolina at Chapel Hill · USNorth Carolina State University · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MRe-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MTargeting the MEKK2-ERK5 Signaling Node in Triple Negative Breast CancerU54CA156733 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MILLER, CHRISTOPHER RYAN · 2010 to 2020
$9.7MMolecular Mechanisms of Type I IFN Induction during Chlamydia InfectionR01AI067678 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2007 to 2018
$3.5MThe Impact of Fc gamma Receptor Signaling on Lupus-Induced AtherosclerosisR01HL130126 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, SHANMUGAM · 2016 to 2019
$1.5MNCATS NIH HHS UL1 TR002489NCI NIH HHS P30 CA016086NCI NIH HHS U54 CA156733NHLBI NIH HHS R01 HL130126NIAID NIH HHS R01 AI067678NIEHS NIH HHS P30 ES010126
6 · The paper itselfAbstract
Chlamydia trachomatis-genital infection in women can be modeled in mice using Chlamydia muridarum. Using this model, it has been shown that the cytokines tumor necrosis factor (TNF)α and interleukin (IL)-1α lead to irreversible tissue damage in the oviducts. In this study, we investigated the contribution of TNFα on IL-1α synthesis in infected epithelial cells. We show that C muridarum infection enhanced TNFα-induced IL-1α expression and release in a mouse epithelial cell line. In addition to IL-1α, several TNFα-induced inflammatory genes were also highly induced, and infection enhanced TNF-induced cell death. In the mouse model of genital infection, oviducts from mice lacking the TNFα receptor displayed minimal staining for IL-1α compared with wild-type oviducts. Our results suggest TNFα and IL-1α enhance each other's downstream effects resulting in a hyperinflammatory response to chlamydial infection. We propose that biologics targeting TNF-induced IL-1α synthesis could be used to mitigate tissue damage during chlamydial infection.
Indexed as
Cell DeathChlamydia InfectionsInterleukin-1alphaTumor Necrosis Factor-alphaAnimalsChlamydia muridarumEpithelial CellsFemaleMiceMice, Inbred C57BLInterleukin-1alphaTumor Necrosis Factor-alphaChlamydia muridarumIL-1αmodelmousemouse epithelial cellsTNFα
Identifiers
PMID34396406
PMCPMC8365113
OpenAlexW3193826401
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