Evidence map›Paper›PMID 34396355›Full record

ArticleCurrent research in microbial sciences2021

Mucormycosis in COVID-19 pandemic: Risk factors and linkages.

Manoj Kumar, Devojit Kumar Sarma, Swasti Shubham, Manoj Kumawat, Vinod Verma, Birbal Singh, Ravinder Nagpal, R R Tiwari

Open access · goldAbstract read
In one paragraph

Article in Current research in microbial sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Brazilian task force for the management of mucormycosis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  3. Mucormycosis and Hearing: A Hospital-Based Study.International archives of otorhinolaryngology · 2025
    Article
  4. Review
  5. Review
  6. Functional Rehabilitation - an Integral Component for Quality of Life in the Holistic Management of COVID-19 Associated Mucormycosis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  7. Mucormycosis: A Rare disease to Notifiable Disease.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. A case of COVID-19-associated mucormycosis due to Lichtheimia ramosa.Journal of clinical laboratory analysis · 2023
    Article
  12. Review
  13. Article
  14. COVID-19-Associated Mucormycosis: An Opportunistic Fungal Infection. A Case Series and Review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Review
  15. Diabetes and COVID-19: Short- and Long-Term Consequences.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Manoj KumarICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.
Devojit Kumar SarmaICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.
Swasti ShubhamICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.
Manoj KumawatICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.
Vinod VermaStem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow - 226014, Uttar Pradesh, India.
Birbal SinghICAR-Indian Veterinary Research Institute Regional Station, Palampur - 176061, Himachal Pradesh, India.
Ravinder NagpalDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32302, United States.
R R TiwariICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhouri, Bhopal - 462030, Madhya Pradesh, India.
ICMR National Institute for Research in Environmental HealthFlorida State University · USIndian Veterinary Research Institute · INSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucormycosis is a serious and potentially fatal fungal infection caused by a type of rare but opportunistic fungal pathogen called mucormycetes. Recently, mucormycosis, also known as black fungus, made severe chaos in India during the second wave (between April and June 2021) of the tragical COVID-19 epidemic by its sudden and devastating surge with up to 50% mortality rate. While the exact cause of its sharp rise suddenly and specifically during the second wave still remains debatable, it has been noted that the people who are diabetic and have recovered from COVID-19 infection are more predisposed to mucormycosis. Nevertheless, the precise reason and mechanism(s) underlying the surge of this deadly infection needs to be investigated to comprehend its pathogenesis and pathological elements and discover rationale preventative/ therapeutic solutions. It is speculated that the indiscriminate use of steroids, antibiotics and zinc as a self-medication practice that increased during the COVID-19 epidemic may have promoted the dysbiosis of gut microbiota thereby inducing immune-suppression and making the risk group highly susceptible to this mycotic disease. In these contexts, this timely article attempts to contemplate and discuss some of the possible factors and potential mechanisms that can help to understand and explain the conundrum of sudden, steep and deadly upsurge of mucormycosis infections during the second wave of COVID-19 epidemic.

Indexed as

Black fungusCOVID-19DysbiosisFungal infectionGut microbiotaMucormycetesMucormycosisSARS-CoV-2Steroids

Identifiers

PMID34396355
PMCPMC8349419
OpenAlexW3189941466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.