Evidence map›Paper›PMID 34396335›Full record

ArticleJACC. CardioOncology2021

3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography.

Suvi Sirkku Tuohinen, Tanja Skyttä, Heini Huhtala, Tuija Poutanen, Vesa Virtanen, Pirkko-Liisa Kellokumpu-Lehtinen, Pekka Raatikainen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Article
  7. Left ventricular diastolic function and cardiotoxic chemotherapy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
    Article
  8. Article
  9. Radiation-Induced Cardiovascular Toxicities.Current treatment options in oncology · 2022
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Suvi Sirkku TuohinenHeart and Lung Center, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland.
Tanja SkyttäDepartment of Oncology, Tampere University Hospital, Tampere, Finland.
Heini HuhtalaFaculty of Social Sciences, Tampere University, Tampere, Finland.
Tuija PoutanenCenter for Child Health Research, Tampere, Finland.
Vesa VirtanenHeart Hospital, Tampere University Hospital, University of Tampere, Tampere, Finland.
Pirkko-Liisa Kellokumpu-LehtinenDepartment of Oncology, Tampere University Hospital, Tampere, Finland.
Pekka RaatikainenHeart and Lung Center, Helsinki University Central Hospital, Helsinki University, Helsinki, Finland.
Tampere University · FIHelsinki University Hospital · FITampere University · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function.

objectivesThe aim of this study was to explore RT-associated changes in left ventricular (LV) diastolic function.

methodsSixty chemotherapy-naive patients with left-sided, early-stage breast cancer were studied with speckle tracking echocardiography at 3 time points: prior to, immediately after, and 3 years after RT. Global and regional early diastolic strain rate (SRe) were quantified, as were parameters of systolic function.

resultsRegional changes in SRe, particularly the apical and anteroseptal segments, were observed over time and were more evident than global changes. The apical SRe declined from a median of 1.24 (interquartile range: 1.01 to 1.39) s

conclusionsRT resulted in changes in the SRe in the apical and anteroseptal segments over 3 years of follow-up. Changes in SRe apical segments were present even in patients with preserved systolic function and were independently associated with RT dose and cardiovascular comorbidities.

Indexed as

breast cancerCI, confidence intervaldiastolic strain rateDLVmax, maximal left ventricular radiation doseGLS, global longitudinal strainIQR, interquartile rangeLAVI, left atrial volume indexed to body surface areaLVEF, left ventricular ejection fractionLV, left ventricularradiotherapyRT, radiotherapyspeckle tracking echocardiographySReapex, apical early diastolic strain rateSRedep, global early diastolic strain rate <1 s-1SRe, early diastolic strain rateSRs, systolic strain rateSR, strain rateΔGLS15, relative decline of more than 15% in global longitudinal strain

Identifiers

PMID34396335
PMCPMC8352342
OpenAlexW3170718996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.