Evidence map›Paper›PMID 34396329›Full record

ArticleJACC. CardioOncology2021

Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States.

Javier Valero-Elizondo, Fouad Chouairi, Rohan Khera, Gowtham R Grandhi, Anshul Saxena, Haider J Warraich, Salim S Virani, Nihar R Desai, Farzan Sasangohar, Harlan M Krumholz and 2 more

Open access · goldAbstract read
In one paragraph

Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Javier Valero-ElizondoDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
Fouad ChouairiCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA.
Rohan KheraCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA.
Gowtham R GrandhiDepartment of Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA.
Anshul SaxenaCenter for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, Florida, USA.
Haider J WarraichDepartment of Medicine, Cardiology Section, VA Boston Healthcare System, Boston, Massachusetts, USA.
Salim S ViraniMichael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
Nihar R DesaiCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA.
Farzan SasangoharCenter for Outcomes Research, Houston Methodist, Houston, Texas, USA.
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, Connecticut, USA.
Nestor F EsnaolaCancer Center, Houston Methodist Research Institute, Houston, Texas, USA.
Khurram NasirDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
Yale New Haven Hospital · USHouston Methodist · USBaptist Hospital of Miami · USBrigham and Women's Hospital · USFox Chase Cancer Center · USMedStar Union Memorial Hospital · USMichael E. DeBakey VA Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundFinancial toxicity (FT) is a well-established side-effect of the high costs associated with cancer care. In recent years, studies have suggested that a significant proportion of those with atherosclerotic cardiovascular disease (ASCVD) experience FT and its consequences.

objectivesThis study aimed to compare FT for individuals with neither ASCVD nor cancer, ASCVD only, cancer only, and both ASCVD and cancer.

methodsFrom the National Health Interview Survey, we identified adults with self-reported ASCVD and/or cancer between 2013 and 2018, stratifying results by nonelderly (age <65 years) and elderly (age ≥65 years). We defined FT if any of the following were present: any difficulty paying medical bills, high financial distress, cost-related medication nonadherence, food insecurity, and/or foregone/delayed care due to cost.

resultsThe prevalence of FT was higher among those with ASCVD when compared with cancer (54% vs. 41%; p < 0.001). When studying the individual components of FT, in adjusted analyses, those with ASCVD had higher odds of any difficulty paying medical bills (odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.09 to 1.36), inability to pay bills (OR: 1.25; 95% CI: 1.04 to 1.50), cost-related medication nonadherence (OR: 1.28; 95% CI: 1.08 to 1.51), food insecurity (OR: 1.39; 95% CI: 1.17 to 1.64), and foregone/delayed care due to cost (OR: 1.17; 95% CI: 1.01 to 1.36). The presence of ≥3 of these factors was significantly higher among those with ASCVD and those with both ASCVD and cancer when compared with those with cancer (23% vs. 30% vs. 13%, respectively; p < 0.001). These results remained similar in the elderly population.

conclusionsOur study highlights that FT is greater among patients with ASCVD compared with those with cancer, with the highest burden among those with both conditions.

Indexed as

ASCVD, atherosclerotic cardiovascular diseaseatherosclerotic cardiovascular diseaseBMI, body mass indexcancerCI, confidence intervalCOST, Comprehensive Score for Financial ToxicityCRF, cardiovascular risk factorfinancial toxicityFT, financial toxicityhealth economicsOOP, out-of-pocketOR, odds ratios

Identifiers

PMID34396329
PMCPMC8352280
OpenAlexW3172303672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.