Evidence map›Paper›PMID 34396327›Full record

ArticleJACC. CardioOncology2021

Risk of Atrial Fibrillation According to Cancer Type: A Nationwide Population-Based Study.

Jun Pil Yun, Eue-Keun Choi, Kyung-Do Han, Sang Hyun Park, Jin-Hyung Jung, Sang Hyeon Park, Hyo-Jeong Ahn, Jae-Hyun Lim, So-Ryoung Lee, Seil Oh

Open access · goldAbstract read
In one paragraph

Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 1 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Safety and efficacy of catheter ablation for atrial fibrillation in cancer survivors: a systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. The B-SCancers · 2025
    Article
  13. Review
  14. 2025 Thai guideline for the diagnosis and management of atrial fibrillation.Asian biomedicine : research, reviews and news · 2025
    Article
  15. Review
  16. Article
  17. Smoking behavior changes and risk of cardiovascular diseases after cancer diagnosis: a nationwide cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  18. CHAThe American journal of cardiology · 2025
    Article
  19. Observational
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jun Pil YunDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Eue-Keun ChoiDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kyung-Do HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Sang Hyun ParkDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jin-Hyung JungDepartment of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sang Hyeon ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hyo-Jeong AhnDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Jae-Hyun LimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
So-Ryoung LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Seil OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Seoul National University Hospital · KRCatholic University of Korea · KRSoongsil University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with cancer have an increased risk of atrial fibrillation (AF). However, there is a paucity of information regarding the association between cancer type and risk of AF.

objectivesThis study sought to evaluate the risk of AF according to the type of cancer.

methodsWe enrolled 816,811 patients who were diagnosed with cancer from the Korean National Health Insurance Service database between 2009 and 2016. Age- and sex-matched noncancer control subjects (1:2; n = 1,633,663) were also selected. Newly diagnosed AF was identified based on the type of cancer.

resultsDuring a median follow-up of 4.5 years, AF was newly diagnosed in 25,356 patients with cancer (6.6 per 1,000 person-years). In multivariable Fine and Gray's regression analysis, cancer was an independent risk factor for incident AF (adjusted subdistribution hazard ratio [aHR]: 1.63; 95% confidence interval [CI]: 1.61 to 1.66). Multiple myeloma showed a higher association with incident AF (aHR: 3.34; 95% CI: 2.98 to 3.75). Esophageal cancer showed the highest risk among solid cancers (aHR: 2.69; 95% CI: 2.45 to 2.95), and stomach cancer showed the lowest association with AF risk (aHR: 1.27; 95% CI 1.23 to 1.32).

conclusionsAlthough patients with cancer were found to have a higher risk of AF, the impact on AF development varied by cancer type.

Indexed as

AF, atrial fibrillationatrial fibrillationcancerCI, confidence intervalCKD, chronic kidney diseaseCNS, central nervous systemCVD, cardiovascular diseaseDM, diabetes mellitusepidemiologyHR, hazard ratioICD-10, International Classification of Diseases–10th RevisionIQR, interquartile rangeNHIS, National Health Insurance Servicetype of cancer

Identifiers

PMID34396327
PMCPMC8352078
OpenAlexW3169465530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.