Evidence map›Paper›PMID 34396153›Full record

ArticleCurrent research in physiology2021

Effect of crista morphology on mitochondrial ATP output: A computational study.

Nasrin Afzal, W Jonathan Lederer, M Saleet Jafri, Carmen A Mannella

Open access · goldAbstract read
In one paragraph

Article in Current research in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  8. Eukaryogenesis From FECA to LECA: Radical Steps Along the Way.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Molecular machineries shaping the mitochondrial inner membrane.Nature reviews. Molecular cell biology · 2025
    Review
  10. Restoring AIBP expression in the retina provides neuroprotection in glaucoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Trophoblast Syncytialization: A Metabolic Crossroads.Results and problems in cell differentiation · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nasrin AfzalKrasnow Institute for Advanced Study and School of Systems Biology, George Mason University, Fairfax, VA, 22030, USA.
W Jonathan LedererCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
M Saleet JafriKrasnow Institute for Advanced Study and School of Systems Biology, George Mason University, Fairfax, VA, 22030, USA.
Carmen A MannellaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · USGeorge Mason University · US

Funding

Mechanistic Modeling of Cellular SystemsR24GM137787 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Pedro Mendes, Ion I. Moraru · 2020 to 2026
$8.9M
Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
NHLBI NIH HHS U01 HL116321NIGMS NIH HHS R24 GM137787
6 · The paper itself

Abstract

Folding of the mitochondrial inner membrane (IM) into cristae greatly increases the ATP-generating surface area,

Indexed as

ATP synthesisComputational modelingCristaeEnergy metabolismKinasesMitochondria

Identifiers

PMID34396153
PMCPMC8360328
OpenAlexW3140675639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.