Evidence map›Paper›PMID 34396048›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021

Lung Function and Symptoms in Post-COVID-19 Patients: A Single-Center Experience.

Nicola Mumoli, Aldo Bonaventura, Alessandra Colombo, Alessandra Vecchié, Marco Cei, José Vitale, Luca Pavan, Antonino Mazzone, Francesco Dentali

Open access · goldAbstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  2. Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  3. Prevalence of post-acute COVID-19 syndrome symptoms at different follow-up periods: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Insights from Transcriptomics: CD163American journal of respiratory cell and molecular biology · 2022
    Review
  9. Article
  10. Long-Term Characteristics of Severe COVID-19: Respiratory Function, Functional Capacity, and Quality of Life.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicola MumoliDepartment of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy.
Aldo BonaventuraDepartment of Internal Medicine, ASST Sette Laghi, Varese, Italy.
Alessandra ColomboDepartment of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy.
Alessandra VecchiéDepartment of Internal Medicine, ASST Sette Laghi, Varese, Italy.
Marco CeiDepartment of Internal Medicine, Cecina Hospital, Cecina (Livorno), Italy.
José VitaleDepartment of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy.
Luca PavanDepartment of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy.
Antonino MazzoneDepartment of Internal Medicine, ASST Ovest Milanese, Magenta (MI), Italy.
Francesco DentaliDepartment of Medicine and Surgery, Insubria University, Varese, Italy.
Aziende Socio Sanitarie Territoriale Ovest MilaneseAziende Socio Sanitarie Territoriale dei Sette LaghiUniversity of Insubria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo address the lack of information about clinical sequelae of coronavirus disease 2019 (COVID-19). PATIENTS AND

methodsPreviously hospitalized COVID-19 patients who were attending the outpatient clinic for post-COVID-19 patients (ASST Ovest Milanese, Magenta, Italy) were included in this retrospective study. They underwent blood draw for complete blood count, C-reactive protein, ferritin, D-dimer, and arterial blood gas analysis and chest high-resolution computed tomography (HRCT) scan. The primary endpoint was the assessment of blood gas exchanges after 3 months. Other endpoints included the assessment of symptoms and chest HRCT scan abnormalities and changes in inflammatory biomarkers after 3 months from hospital admission.

resultsEighty-eight patients (n = 65 men; 73.9%) were included. Admission arterial blood gas analysis showed hypoxia and hypocapnia and an arterial partial pressure of oxygen/fractional inspired oxygen ratio of 271.4 (interquartile range [IQR]: 238-304.7) mm Hg that greatly improved after 3 months (426.19 [IQR: 395.2-461.9] mm Hg,

conclusionWhereas inflammatory biomarker levels normalized after 3 months, signs of lung damage persisted for a longer period. These findings support the need for implementing post-COVID-19 outpatient clinics to closely follow-up COVID-19 patients after hospitalization.

Indexed as

ABG, arterial blood gasCOVID-19, coronavirus disease 2019CRP, C-reactive proteinCT, computed tomographyDOE, dyspnea on exertionGGO, ground-glass opacityHRCT, high-resolution computed tomographyIQR, interquartile rangePaCO2, arterial partial pressure of carbon dioxidePaO2, arterial partial pressure of oxygenPaO2/FiO2, ratio of arterial partial pressure of oxygen to fractional inspired oxygenPFT, pulmonary function testSARS-CoV-2, severe acute respiratory syndrome coronavirus 2V/Q, ventilation/perfusion ratio

Identifiers

PMID34396048
PMCPMC8352649
OpenAlexW3187272585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.