ArticleACS omega2021
Efficient Bioproduction of Indigo and Indirubin by Optimizing a Novel Terpenoid Cyclase XiaI in
Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Insights into the Regulation of Indigo Production in an EngineeredFoods (Basel, Switzerland) · 2026Article
- Engineering yeast for sustainable bioproduction of tryptophan-derived aromatic compounds.FEMS yeast research · 2026Review
- Advances in microbial biosynthesis of indirubin.Chinese herbal medicines · 2026Review
- Advances in the microbial biosynthesis of ʟ-tryptophan and its derivatives.Biodesign research · 2025Review
- A novel ene-reductase fromRSC advances · 2025Article
- Bioprospecting cultivable bacteria associated with deep sea (mesopelagic) fish of the North Atlantic Ocean.Natural products and bioprospecting · 2025Article
- Investigations of the Flavin-Dependent Monooxygenase PhzO Involved in Phenazine Biosynthesis.Microbial biotechnology · 2025Article
- Finding of the positive impact of glucose on the production of indican over indigo in engineered Escherichia coli.Journal of industrial microbiology & biotechnology · 2024Article
- Functional characterization of a novel flavin reductase from a deep-sea sediment metagenomic library and its application for indirubin production.Applied and environmental microbiology · 2024Article
- Indigo production goes green: a review on opportunities and challenges of fermentative production.World journal of microbiology & biotechnology · 2024Review
- Enzymatic synthesis of indigo derivatives by tuning P450 BM3 peroxygenases.Synthetic and systems biotechnology · 2023Article
- Synthetic microbes and biocatalyst designs in Thailand.Biotechnology notes (Amsterdam, Netherlands) · 2023Review
- Expanding the application of tryptophan: Industrial biomanufacturing of tryptophan derivatives.Frontiers in microbiology · 2023Review
- Production of indigo by recombinant bacteria.Bioresources and bioprocessing · 2023Review
- Discovery of New Phenylacetone Monooxygenase Variants for the Development of Substituted Indigoids through Biocatalysis.International journal of molecular sciences · 2022Article
- Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin.Bioresources and bioprocessing · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blue indigo dye, an important natural colorant, is used for textiles and food additives worldwide, while another red isomer, indirubin, is the major active ingredient of a traditional Chinese medicine named "Danggui Longhui Wan" for treating various diseases including granulocytic leukemia, cancer, and Alzheimer's disease. In this work, we constructed a new and highly efficient indigoid production system by optimizing a novel terpenoid cyclase, XiaI, from the xiamycin biosynthetic pathway. Through introducing the flavin-reducing enzyme Fre, tryptophan-lysing and -importing enzymes TnaA and TnaB, and H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.