Evidence map›Paper›PMID 34395993›Full record

ArticleACS omega2021

Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents.

Verrill M Norwood, Claribel Murillo-Solano, Michael G Goertzen, Beau R Brummel, David L Perry, James R Rocca, Debopam Chakrabarti, Robert William Huigens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Verrill M NorwoodDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.
Claribel Murillo-SolanoDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.
Michael G GoertzenDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID https://orcid.org/0000-0003-4005-6685
Beau R BrummelDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID https://orcid.org/0000-0002-5247-9418
David L PerryDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.
James R RoccaDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States.ORCID https://orcid.org/0000-0002-4554-3119
Robert William HuigensDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID https://orcid.org/0000-0003-3811-2721
University of Florida · USUniversity of Central Florida · US

Funding

Indole Alkaloids and Phenazine Antibiotics: New Platforms for Drug DiscoveryR35GM128621 · NIGMS · UNIVERSITY OF FLORIDA · PI HUIGENS, ROBERT WILLIAM · 2018 to 2022
$1.7M
Chemistry-Biology Interface Training Program at the University of FloridaT32GM136583 · NIGMS · UNIVERSITY OF FLORIDA · PI Chenglong Li · 2020 to 2026
$1.1M
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIGMS NIH HHS R35 GM128621NIGMS NIH HHS T32 GM136583NIH HHS S10 OD021758
6 · The paper itself

Abstract

There is a significant need for new agents to combat malaria, which resulted in ∼409,000 deaths globally in 2019. We utilized a ring distortion strategy to create complex and diverse compounds from vincamine with the goal of discovering molecules with re-engineered biological activities. We found compound

Identifiers

PMID34395993
PMCPMC8359148
OpenAlexW3186933063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.