ArticleJournal of dental anesthesia and pain medicine2021
Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6-10 years: a randomized control study.
Article in Journal of dental anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Comparative Evaluation of Pain Perception Following Topical Application of Clove Oil, EMLA 5%, and Lignocaine Hydrochloride Gel 2% as a Pre-anesthetic Agent in Children Aged 7-10 Years: A Randomized Controlled Study.International journal of clinical pediatric dentistry · 2026Article
- Evaluation of phytochemical components, cytotoxicity, and molecular docking ofJournal of dental anesthesia and pain medicine · 2026Article
- Comparative Evaluation of Effectiveness of Benzocaine Gel and Ice for Pain Management in Children during Local Anesthetic Administration by CCLAD: A Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2025Article
- AnInternational journal of clinical pediatric dentistry · 2024Article
- A comparative evaluation of peppermint oil and lignocaine spray as topical anesthetic agents prior to local anesthesia in children: a randomized clinical trial.Journal of dental anesthesia and pain medicine · 2024Article
- Herbal topical anesthetics in dentistry: an exploratory review.Journal of dental anesthesia and pain medicine · 2022Review
- Effectiveness of topical ajwain oil in reducing pain during local anaesthesia administration in paediatric dental patients: A randomized controlled trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the field of dentistry, topical anesthetics play an important role in reducing pain during needle pricks. The anesthetic property of betel leaves remain unexplored, even though they have been widely used for the treatment of various ailments. The purpose of this study was to compare and evaluate pain perception following topical application of lignocaine gel, clove gel, ice, and newly developed betel leaf extract gel during intraoral injection in children.
methodsSixty children aged 6-10 years who met the inclusion criteria were divided into four groups. Topical anesthetic agents, 2% lignocaine (Lox-2% Jelly, Neon, Mumbai, India), 4.7% clove gel (Pain Out Dental Gel, Colgate Palmolive India Ltd, Solan, India), 10% betel leaf extract gel, and ice were applied to each group for one min, followed by administration of infiltration anesthesia. Pain perception was analyzed during needle insertion. The Wong Bakers FACES pain rating scale (WBFPRS) was used for subjective assessment and the Sound, Eye, Motor (SEM) scale for objective assessment. Recorded values were tabulated and subjected to appropriate statistical analysis using SPSS software with a P value set at 0.05.
resultsThe clove oil and betel leaf groups demonstrated the highest WBFPRS scores, followed by the ice and lignocaine groups. The clove, betel leaf extract, and ice groups showed equal and highest SEM scores, followed by the lignocaine group. The mean WBFPRS and mean SEM scores were statistically significant.
conclusionBetel leaf extract gel is effective in reducing pain and can act as an alternative topical anesthetic agent.
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