Evidence map›Paper›PMID 34395900›Full record

ArticleJournal of dental anesthesia and pain medicine2021

Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6-10 years: a randomized control study.

Raghavendra Havale, Dhanu G Rao, Shrutha S P, Kanchan M Tuppadmath, Namratha Tharay, Irin Mathew, Kausar E Taj

Open access · hybridAbstract read
In one paragraph

Article in Journal of dental anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Evaluation of phytochemical components, cytotoxicity, and molecular docking ofJournal of dental anesthesia and pain medicine · 2026
    Article
  3. Article
  4. AnInternational journal of clinical pediatric dentistry · 2024
    Article
  5. Article
  6. Herbal topical anesthetics in dentistry: an exploratory review.Journal of dental anesthesia and pain medicine · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Raghavendra HavaleDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0001-8811-3445
Dhanu G RaoDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0002-4032-4582
Shrutha S PDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0002-9426-2719
Kanchan M TuppadmathDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0002-9485-5493
Namratha TharayDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0002-2380-8868
Irin MathewDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0002-0781-3835
Kausar E TajDepartment of Pediatric and Preventive Dentistry, Academy of Medical Education Dental College and Hospital, Raichur, India.ORCID https://orcid.org/0000-0001-6920-6486
Navodaya Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the field of dentistry, topical anesthetics play an important role in reducing pain during needle pricks. The anesthetic property of betel leaves remain unexplored, even though they have been widely used for the treatment of various ailments. The purpose of this study was to compare and evaluate pain perception following topical application of lignocaine gel, clove gel, ice, and newly developed betel leaf extract gel during intraoral injection in children.

methodsSixty children aged 6-10 years who met the inclusion criteria were divided into four groups. Topical anesthetic agents, 2% lignocaine (Lox-2% Jelly, Neon, Mumbai, India), 4.7% clove gel (Pain Out Dental Gel, Colgate Palmolive India Ltd, Solan, India), 10% betel leaf extract gel, and ice were applied to each group for one min, followed by administration of infiltration anesthesia. Pain perception was analyzed during needle insertion. The Wong Bakers FACES pain rating scale (WBFPRS) was used for subjective assessment and the Sound, Eye, Motor (SEM) scale for objective assessment. Recorded values were tabulated and subjected to appropriate statistical analysis using SPSS software with a P value set at 0.05.

resultsThe clove oil and betel leaf groups demonstrated the highest WBFPRS scores, followed by the ice and lignocaine groups. The clove, betel leaf extract, and ice groups showed equal and highest SEM scores, followed by the lignocaine group. The mean WBFPRS and mean SEM scores were statistically significant.

conclusionBetel leaf extract gel is effective in reducing pain and can act as an alternative topical anesthetic agent.

Indexed as

ChildrenClove OilIceLignocainePain Perception

Identifiers

PMID34395900
PMCPMC8349677
OpenAlexW3192517237

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.