Evidence map›Paper›PMID 34395771›Full record

ArticleBio-protocol2018

Trace Fear Conditioning: Procedure for Assessing Complex Hippocampal Function in Mice.

Vijendra Sharma, Noah Cohen, Rapita Sood, Hadile Ounallah-Saad, Shunit Gal-Ben-Ari, Kobi Rosenblum

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PubMed Full text at PMC Publisher
In one paragraph

Article in Bio-protocol, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vijendra SharmaDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Noah CohenDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Rapita SoodDepartment of Biochemistry, McGill University, Montréal, Québec, Canada.
Hadile Ounallah-SaadSagol Department of Neurobiology, University of Haifa, Haifa, Israel.
Shunit Gal-Ben-AriSagol Department of Neurobiology, University of Haifa, Haifa, Israel.
Kobi RosenblumSagol Department of Neurobiology, University of Haifa, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The trace fear conditioning protocol is designed to measure hippocampal function in mice. The protocol includes a neutral conditioned stimulus (tone) and an aversive unconditioned stimulus (shock), separated in time by a trace interval. The trace interval between the tone and the shock critically involves the hippocampus and could be used to evaluate hippocampal-dependent learning and memory. In this protocol, we presented mice with five pairings of tone and shock separated by a 20 sec trace interval. Freezing was measured 24 h after conditioning to evaluate contextual memory by placing mice in the conditioned chamber. In addition, 48 h after conditioning, freezing was measured in a dark chamber, which served as a different context. This method enables precise detection of hippocampal-dependent learning and memory following pharmacological and genetic manipulations that impair or enhance hippocampal function.

Indexed as

Contextual memoryHippocampus functionLearning and memory deficitsMemory enhancementTrace fear conditioning (TFC)

Identifiers

PMID34395771
PMCPMC8328640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.