Evidence map›Paper›PMID 34395398›Full record

ArticleFrontiers in bioengineering and biotechnology2021

The Influence of Kinematic Constraints on Model Performance During Inverse Kinematics Analysis of the Thoracolumbar Spine.

Mohammad Mehdi Alemi, Katelyn A Burkhart, Andrew C Lynch, Brett T Allaire, Seyed Javad Mousavi, Chaofei Zhang, Mary L Bouxsein, Dennis E Anderson

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. A stiffness-dependent method to estimate spine kinematics and loading reveals the impact of nonlinear mechanics during lifting tasks.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
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  5. Cervical disk arthroplasty: The new gold standard?Bulletin of the Hospital for Joint Disease (2013) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Mehdi AlemiCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Katelyn A BurkhartCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Andrew C LynchCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Brett T AllaireCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Seyed Javad MousaviCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Chaofei ZhangDepartment of Automotive Engineering, Tsinghua University, Beijing, China.
Mary L BouxseinCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Dennis E AndersonCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, United States.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Training in Orthopaedic and Musculoskeletal Clinical ResearchT32AR055885 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL, LOSINA, ELENA · 2008 to 2023
$4.0M
Influence of Spinal Loading on Vertebral FractureR01AR073019 · NIAMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUXSEIN, MARY L, SNYDER, BRIAN D · 2018 to 2022
$2.8M
Age-related Changes in Thoracic Spine BiomechanicsR00AG042458 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERSON, DENNIS · 2015 to 2017
$735k
Evaluation of a Novel Passive Back-Support Exosuit (BSE) for Back Injury Prevention in Older AdultsF32AG071308 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ALEMI, MOHAMMAD MEHDI · 2021 to 2022
$126k
NCATS NIH HHS UL1 TR001102NIAMS NIH HHS R01 AR073019NIAMS NIH HHS T32 AR055885NIA NIH HHS F32 AG071308NIA NIH HHS R00 AG042458
6 · The paper itself

Abstract

Motion analysis is increasingly applied to spine musculoskeletal models using kinematic constraints to estimate individual intervertebral joint movements, which cannot be directly measured from the skin surface markers. Traditionally, kinematic constraints have allowed a single spinal degree of freedom (DOF) in each direction, and there has been little examination of how different kinematic constraints affect evaluations of spine motion. Thus, the objective of this study was to evaluate the performance of different kinematic constraints for inverse kinematics analysis. We collected motion analysis marker data in seven healthy participants (4F, 3M, aged 27-67) during flexion-extension, lateral bending, and axial rotation tasks. Inverse kinematics analyses were performed on subject-specific models with 17 thoracolumbar joints allowing 51 rotational DOF (51DOF) and corresponding models including seven sets of kinematic constraints that limited spine motion from 3 to 9DOF. Outcomes included: (1) root mean square (RMS) error of spine markers (measured vs. model); (2) lag-one autocorrelation coefficients to assess smoothness of angular motions; (3) maximum range of motion (ROM) of intervertebral joints in three directions of motion (FE, LB, AR) to assess whether they are physiologically reasonable; and (4) segmental spine angles in static ROM trials. We found that RMS error of spine markers was higher with constraints than without (

Indexed as

degrees of freedomdynamic movementoptoelectronic motion capturesmoothness of motionspine motion

Identifiers

PMID34395398
PMCPMC8358679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.