Evidence map›Paper›PMID 34395344›Full record

ArticleFrontiers in pediatrics2021

Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).

Marianne Ifversen, Roland Meisel, Petr Sedlacek, Krzysztof Kalwak, Luisa Sisinni, Daphna Hutt, Thomas Lehrnbecher, Adriana Balduzzi, Tamara Diesch, Andrea Jarisch and 35 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Second allogeneic transplants in children: twelve years of experienceBiomedica : revista del Instituto Nacional de Salud · 2026
    Article
  4. Article
  5. Article
  6. The psychological effects of protective isolation on haematological stem cell transplant patients: an integrative, descriptive review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. [Advances in nutritional support for children undergoing hematopoietic stem cell transplantation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 20 institutions in 17 countries.

Marianne IfversenDepartment of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Roland MeiselDivision of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Petr SedlacekDepartment of Pediatric Hematology and Oncology, Hospital Motol, Charles University, Prague, Czechia.
Krzysztof KalwakDepartment of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland.
Luisa SisinniPediatric Hematology, Oncology and Hematopoietic Stem Cell Transplantation Unit, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
Daphna HuttDivision of Pediatric Hematology, Oncology and Bone Marrow Transplantation, The Edmond and Lily Safra Children's Hospital, Tel Aviv, Israel.
Thomas LehrnbecherDivision for Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Adriana BalduzziClinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.
Tamara DieschDivision of Pediatric Hematology-Oncology, University Children's Hospital of Basel, Basel, Switzerland.
Andrea JarischDivision for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Tayfun GüngörDepartment of Hematology, Immunology, Oncology and Stem Cell Transplantation, University Children's Hospital Zürich, Zurich, Switzerland.
Jerry SteinDivision of Pediatric Hematoloy-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Isaac YanivDivision of Pediatric Hematoloy-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Halvard BonigInstitute for Transfusion Medicine and Immunohematology of Goethe University, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany.
Michaela KuhlenPaediatrics and Adolescent Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
Marc AnsariDivision of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland.
Tiago NavaDivision of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland.
Jean-Hugues DalleHematology and Immunology Department, Robert-Debre Hospital, Assistance Publique-Hopitaux de Paris and University of Paris, Paris, France.
Cristina Diaz-de-HerediaDepartment of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Eugenia TrigosoPaediatric Transplant Unit, Hospital University and Polytechnic, Hospital LA FE, Valencia, Spain.
Ulrike FalkenbergStem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Mihaela HartmannStem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Marco DeianaPaediatric Haematology-Oncology Department, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy.
Marta CanesiClinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.
Chiara BroggiClinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy.
Alice BertainaDepartment of Pediatric Hematology-Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Bambino Gesù, Rome, Italy.
Brenda GibsonDepartment of Paediatric Haematology-Oncology, Royal Hospital for Children, Glasgow, United Kingdom.
Gergely KrivanCentral Hospital of Southern Pest, National Institute of Hematology and Infectious Disease, Budapest, Hungary.
Kim VettenrantaChildren's Hospital and Pediatric Research Center, University of Helsinki, Helsinki, Finland.
Toni MaticDepartment of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.
Jochen BuechnerDepartment of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.
Anita LawitschkaStem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Christina PetersStem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
Akif YesilipekDepartment of Pediatric Hematology and Pediatric Stem Cell Transplantation Unit, Antalya and Göztepe Medicalpark Hospitals, Antalya, Turkey.
Koray YalçinDepartment of Pediatric Bone Marrow Transplantation Unit, Medicalpark Göztepe Hospital, Istanbul, Turkey.
Giovanna LucchiniDepartment of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, National Health Service Foundation Trust, London, United Kingdom.
Shahrzad BakhtiarDivision for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Dominik TurkiewiczDivision of Molecular Hematology, Lund University, Lund, Sweden.
Riitta NiinimäkiDepartment of Pediatrics, Oulu University Hospital, Oulu, Finland.
Jacek WachowiakDepartment of Pediatric Oncology, Hematology and Hematopoietic Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
Simone CesaroPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Arnaud DalissierEuropean Society for Blood and Marrow Transplantation Paris Office, Hôpital Saint Antoine, Paris, France.
Selim CorbaciogluDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital of Regensburg, Regensburg, Germany.
Andre Manfred WillaschDivision for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Peter BaderDivision for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany.
Goethe University Frankfurt · DEMedical University of Vienna · ATAzienda Ospedaliera San Gerardo · ITSchneider Children's Medical Center · ILUniversity Hospital of Geneva · CHAssistance Publique – Hôpitaux de Paris · FRAzienda Ospedaliera Universitaria Integrata Verona · ITCharles University · CZCopenhagen University Hospital · DKEdmond and Lily Safra Children's Hospital · ILGerman Red Cross · DEGreat Ormond Street Hospital for Children NHS Foundation Trust · GBHeinrich Heine University Düsseldorf · DEHôpital Saint-Antoine · FRHospital de Sant Pau · ESHospital Universitari i Politècnic La Fe · ESIstanbul Eye Hospital · TRLund University · SEOslo University Hospital · NOOulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child's and family's daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.

Indexed as

allogeneic hematological stem cell transplantationantibiotic prophylactic therapychildreninfection precautionvaccination

Identifiers

PMID34395344
PMCPMC8358428
OpenAlexW3191873257

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.