Evidence map›Paper›PMID 34395301›Full record

ArticleEuropean thyroid journal2021

Calcitonin Levels in Thyroid Disease Are Not Affected by Autoimmune Thyroiditis or Differentiated Thyroid Carcinoma.

Fabio Maino, Cristina Dalmiglio, Nicoletta Benenati, Michele Campanile, Tania Pilli, Raffaella Forleo, Lucia Brilli, Cristina Ciuoli, Silvia Cantara, Marco Capezzone and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European thyroid journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Calcitonin: current concepts and differential diagnosis.Therapeutic advances in endocrinology and metabolism · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Fabio MainoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Cristina DalmiglioDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Nicoletta BenenatiDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Michele CampanileDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Tania PilliDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Raffaella ForleoDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Lucia BrilliDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Cristina CiuoliDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Silvia CantaraDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Marco CapezzoneDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Alessandra CartocciDepartment of Medical Biotechnologies, University of Siena, Siena, Italy.
Furio PaciniHumanitas Clinical Institute, Humanitas University, Rozzano, Italy.
Maria Grazia CastagnaDepartment of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
University of Siena · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAssociation between hypercalcitoninemia and pathological conditions such as autoimmune thyroiditis (AIT) or differentiated thyroid carcinoma (DTC) has been addressed, with conflicting results. We evaluated the prevalence and the clinical relevance of elevated basal serum calcitonin (CT) levels in non-neoplastic (nodular goiter [NG] and AIT) and neoplastic thyroid diseases (DTC).

methodsWe retrospectively evaluated 3,250 consecutive patients with thyroid nodular disease who underwent fine-needle aspiration cytology with adequate sample. After exclusion of medullary thyroid cancer (MTC) patients were divided according to the presence/absence of thyroid autoimmunity into NG or nodular autoimmune thyroiditis (N-AIT) and, according to cytological results, in benign or suspicious/malignant nodules.

resultsOne hundred ninety-seven/3,250 patients (6.0%) showed CT level >10 pg/mL. In 11/3,250 (0.3%) cases, a final histological diagnosis of MTC was made, while the remaining 186/3,250 patients (5.7%) had non-MTC-related hypercalcitoninemia (CT > 10 pg/mL). According to cytological diagnosis, the rate of hypercalcitoninemia was similar in class II and class V-VI groups (5.4 vs. 6.9%,

conclusionsAIT and DTC seem not to affect serum CT levels in patients with thyroid nodules. Therefore, hypercalcitoninemia, in these patients, should be submitted to the same diagnostic workup than patients without AIT or DTC.

Indexed as

Autoimmune thyroiditisCalcitoninDifferentiated thyroid cancerMedullary thyroid cancer

Identifiers

PMID34395301
PMCPMC8314776
OpenAlexW3180852439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.