ArticleFrontiers in oncology2021
Cancer Cells Can Exhibit a Sparing FLASH Effect at Low Doses Under Normoxic
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Examining the Occurrence of the FLASH Effect in Animal Models: A Systematic Review and Meta-Analysis of Ultra-High Dose Rate Proton or Carbon Ion Irradiation.Technology in cancer research & treatmentPooled it
- Mitochondrial remodeling after conventional and ultra-high dose rate irradiation in head and neck carcinoma cells in vitro.Clinical and translational radiation oncology · 2026Article
- FLASH radiotherapy: physico-chemical considerations on ionisation tracks, radical reactions, and the role of oxygen.Radiation oncology (London, England) · 2026Review
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Towards FLASH Radiotherapy in Lung Cancer: A Review on Preclinical Evidence and Technical Feasibility.Cancers · 2026Review
- For ultra-high dose rate carbon-ion irradiation, comparable beam parameters induce the equivalent cell sparing (FLASH) effect.Journal of radiation research · 2026Article
- Article
- Effect of oxygen and nanoparticles on human skin and colon cells exposed to synchrotron-based X-ray FLASH beams.Journal of synchrotron radiation · 2026Article
- Development of a temperature-dependent chemical simulation code based on PHITS for water radiolysis from 0 to 350 °C.Scientific reports · 2026Article
- Research progresses on FLASH radiotherapy and its application for the treatment of digestive system tumors.Discover oncology · 2026Review
- Is Ultrahigh Dose Rate Critical for the Effectiveness of Microbeam Radiation Therapy in a Broad-Beam Combined Treatment?Advances in radiation oncology · 2026Article
- Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.PloS one · 2026Article
- Early molecular changes induced by FLASH irradiation in MCF10A and MDA-MB-231 breast cell lines.Frontiers in oncology · 2026Article
- FLASH Radiotherapy in Lung Cancer: Translational Mechanisms, Preclinical Evidence, and Barriers.Cureus · 2026Review
- Synergizing radiotherapy and immunotherapy for locally advanced gastric cancer: evolving paradigms and future directions.Frontiers in immunology · 2026Review
- Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect.Cell death & disease · 2025Article
- Article
- The Biophysics of Flash Radiotherapy: Tools for Measuring Tumor and Normal Tissues Microenvironment.Antioxidants (Basel, Switzerland) · 2025Review
- Effectiveness of FLASH vs. Conventional Dose Rate Radiotherapy in a Model of Orthotopic, Murine Breast Cancer.Cancers · 2025Article
- Impact of Ultra-High-Dose-Rate Irradiation on DNA: Single-Strand Breaks and Base Damage.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIrradiation with ultra-high dose rate (FLASH) has been shown to spare normal tissue without hampering tumor control in several
methodsSeven cancer cell lines (MDA-MB-231, MCF7, WiDr, LU-HNSCC4, HeLa [early passage and subclone]) and normal lung fibroblasts (MRC-5) were irradiated with doses ranging from 0 to 12 Gy using FLASH (≥800 Gy/s) or conventional dose rates (CONV, 14 Gy/min), with a 10 MeV electron beam from a clinical linear accelerator. Surviving fraction (SF) was determined with clonogenic assays. Three cell lines were further studied for radiation-induced DNA-damage foci using a 53BP1-marker and for cell cycle synchronization after irradiation.
resultsA tendency of increased survival following FLASH compared with CONV was suggested for all cell lines, with significant differences for 4/7 cell lines. The magnitude of the FLASH-sparing expressed as a dose-modifying factor at SF=0.1 was around 1.1 for 6/7 cell lines and around 1.3 for the HeLa
conclusionWe have found a FLASH effect appearing at low doses under normoxic conditions for several cell lines
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.