Posterior Reversible Encephalopathy Syndrome Is the Common Cause of New-Onset Seizures in the Peripartum Period: A Tertiary Hospital-Based Study in South India.

Jagarlapudi Mk Murthy, Shyam K Jaiswal, Keshava Anand Gaade

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Article in Journal of epilepsy research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors at 1 institution in 1 country.

Jagarlapudi Mk MurthyDepartment of Neurology, CARE Institute of Neurosciences, CARE Hospitals, Hyderabad, India.

Shyam K JaiswalDepartment of Neurology, CARE Institute of Neurosciences, CARE Hospitals, Hyderabad, India.

Keshava Anand GaadeDepartment of Neurology, CARE Institute of Neurosciences, CARE Hospitals, Hyderabad, India.

CARE Hospitals · IN

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeTo study the aetiolgic spectrum of new-onset seizures in the peripartum period in south India.

methodsThis is a retrospective analysis of case records of women with new-onset seizures in the peripartum period admitted between 2005 and 2018 (13 years).

resultsOf the 41 women (mean age, 26.20 years; range, 19-35 years) admitted, 20 patients (48.7%) had hypertensive disorders of pregnancy (HDP). Generalized tonic-clonic seizure (88%) was the common seizure type. The aetiologies of new-onset seizures were: 1) pregnancy-related aetiologies in 33 (80.5%) and 2) non-pregnancy-related aetiologies in eight (19.5%). Of the pregnancy-related aetiologies, posterior reversible encephalopathy syndrome (PRES) was the commonest cause in 24 patients (58.5%). Seizure cluster presentation was common in patients with PRES (

conclusionsPRES was the common cause of new-onset seizures in peripartum period in this cohort. Endemic infections of CNS accounted for 7.3% of the total aetiological spectrum. This study suggests that the possibility of PRES should be considerd in woman with HDP and seizure cluster in peripartum period.

Indexed as

Cerebral venous thrombosisHypertensive disorders of pregnancyNew-onset seizurePeripartum periodPosterior reversible leukoencephalopathy syndrome

Identifiers

PMID34395223

DOI10.14581/jer.21007

PMCPMC8357549

OpenAlexW3192586164

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