Evidence map›Paper›PMID 34395199›Full record

ArticleAfrican journal of laboratory medicine2021

Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe.

Faithful Makita-Chingombe, Anthony T Podany, Timothy Mykris, Farai Muzambi, Richard W Browne, Andrew J Ocque, Robin DiFrancesco, Lee C Winchester, Courtney V Fletcher, Tinashe Mudzviti and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Faithful Makita-ChingombeInternational Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.ORCID 0000-0001-6897-7502
Anthony T PodanyAntiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID https://orcid.org/0000-0002-8371-0379
Timothy MykrisAntiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID https://orcid.org/0000-0002-0959-6563
Farai MuzambiInternational Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.ORCID https://orcid.org/0000-0003-3124-1889
Richard W BrowneTranslational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.ORCID https://orcid.org/0000-0002-7685-1608
Andrew J OcqueTranslational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.ORCID https://orcid.org/0000-0001-6169-8068
Robin DiFrancescoTranslational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.ORCID https://orcid.org/0000-0001-7418-2546
Lee C WinchesterAntiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID https://orcid.org/0000-0002-6118-024X
Courtney V FletcherAntiviral Pharmacology Laboratory, University of Nebraska Medical Center, Omaha, Nebraska, United States.ORCID 0000-0002-3703-7849
Tinashe MudzvitiInternational Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-9817-7108
Charles C MapongaInternational Pharmacology Specialty Laboratory, School of Pharmacy, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.ORCID https://orcid.org/0000-0001-6340-5994
Gene D MorseTranslational Pharmacology Research Core, Center for Integrated Global Biomedical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, United States.ORCID https://orcid.org/0000-0001-6758-0941
University at Buffalo, State University of New York · USUniversity of Nebraska Medical Center · USUniversity of Zimbabwe · ZW

Funding

Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
HIV Research Training ProgramD43TW010313 · FIC · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Charles Enos Chiedza Maponga, Gene D. Morse · 2016 to 2026
$3.2M
Clinical Pharmacology of Efavirenz Combined with High Dose RifapentineK23AI134307 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PODANY, ANTHONY T · 2018 to 2022
$819k
FIC NIH HHS D43 TW010313NIAID NIH HHS HHSN272200800019CNIAID NIH HHS HHSN272201500006CNIAID NIH HHS K23 AI134307NIAID NIH HHS P30 AI078498NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator capacities. Quantitation of plasma nevirapine in samples from the AIDS Clinical Trials Group protocol 5279 was compared between the University of Nebraska Medical Center PSL and the University of Zimbabwe PSL. Both PSLs employed internally developed methods utilising reverse-phase high-performance liquid chromatography with ultraviolet detection. Eighty-seven percent of the cross-validation results exhibited ± 20% difference.

Indexed as

cross-validationhigh-performance liquid chromatographyHIVroot-cause analysis

Identifiers

PMID34395199
PMCPMC8335789
OpenAlexW3179206451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.