Evidence map›Paper›PMID 34395047›Full record

ArticleGeriatric orthopaedic surgery & rehabilitation2021

Does Superior Bone Health Promote a Longer Lifespan?

Stephanie R Dayer, Simon C Mears, Amanda K Pangle, Priya Mendiratta, Jeanne Y Wei, Gohar Azhar

Abstract read
In one paragraph

Article in Geriatric orthopaedic surgery & rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Association between vertebral fractures and brain volume: insights from a community cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  2. Bone/Muscle Interaction as a Good Biomarker for Lifespan and Quality.Geriatric orthopaedic surgery & rehabilitation · 2022
    Article
  3. Superior Bone Health for Promoting Longer and Better Lives.Geriatric orthopaedic surgery & rehabilitation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie R DayerDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USA.
Simon C MearsDepartment of Orthopaedic Surgery, UAMS, Little Rock, AR, USA.ORCID https://orcid.org/0000-0002-0068-0283
Amanda K PangleDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USA.
Priya MendirattaDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USA.
Jeanne Y WeiDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USA.
Gohar AzharDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, UAMS, Little Rock, AR, USA.

Funding

RESOURCE CORE 3: ANALYTICAL COREP30AG028718 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI WEI, JEANNE Y · 2011 to 2015
$5.1M
NIA NIH HHS P30 AG028718
6 · The paper itself

Abstract

introductionPublic health achievements throughout the last century have resulted in a steady increase in life expectancy. An emergent subset has distinguished themselves, living well beyond the ninth decade by avoiding or delaying the onset of most age-related diseases, including bone diseases and fractures. In this study, we evaluated the bone health of the oldest community-dwelling individuals living in rural Arkansas.

methods299 patients aged ≥90 years were retrospectively reviewed for recorded fractures within 12 years prior to the investigation period. Records were also examined for medications and test results pertinent to bone health, including thyroid stimulating hormone, vitamin D levels, hematocrit, hemoglobin, body mass index, and bone densitometric values.

results68 patients (23%) had at least one fracture documented, and 15 had >1 fracture. 40% of patients with fractures had osteoporosis and 28% had osteopenia, respectively. 232 patients (78%) had no documented fractures, and of these, only 18% had osteoporosis and 16% had osteopenia. No significant clinical markers were found among the very old to explain the relatively low occurrence of fractures.

conclusionsPatients over 90 years of age had an overall low prevalence of fractures and relative preservation of bone health, suggesting a preserved bone molecular profile in these individuals. Epigenetic factors and activity levels might also have favorably affected bone health. The low percentage of osteoporosis and fractures likely reduced the morbidity and mortality in this population, potentially contributing to their overall longevity.

Indexed as

agingbone healthlongevityosteoporosis

Identifiers

PMID34395047
PMCPMC8358490

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.