Evidence map›Paper›PMID 34394823›Full record

ArticleOxidative medicine and cellular longevity2021

Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma.

Feng Gao, Guozhong Liu, Jingwen Wang, Shirong Huang, Fadian Ding, Wei Lian, Xiaoting Lv, Yujia Guo, Xiangqun Fan, Sheng Zhang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer.International journal of molecular sciences · 2025
    Review
  2. Frontiers in cell and developmental biology · 2025
    Article
  3. Review
  4. Review
  5. CGRP: A New Endogenous Cell Stemness Maintenance Molecule.Oxidative medicine and cellular longevity · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Feng Gao *Department of Pathology, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.ORCID https://orcid.org/0000-0001-7420-2498
Guozhong Liu *Department of Hepatobiliary Surgery, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Jingwen Wang *Department of Pathology, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Shirong HuangDepartment of Laboratory Medicine, Fujian Medical University, 350004 Fuzhou, China.ORCID https://orcid.org/0000-0001-8257-8671
Fadian DingDepartment of Hepatobiliary Surgery, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.ORCID https://orcid.org/0000-0002-9868-3094
Wei LianDepartment of Hepatobiliary Surgery, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.
Xiaoting LvDepartment of Respiratory, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China.ORCID https://orcid.org/0000-0003-4100-6401
Yujia GuoCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China.
Xiangqun FanCenter of Prenatal Screening, Fujian Provincial Maternity and Children's Hospital, Fujian Medical University, Fuzhou 350005, China.
Sheng ZhangDepartment of Pathology, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China.ORCID https://orcid.org/0000-0003-3063-2917
Qicai LiuCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China.ORCID https://orcid.org/0000-0003-1766-9395
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcitonin gene-related peptide (CGRP) plays a diverse and intricate role in chronic low-grade inflammation and is closely related to specific cancers. It includes two subtypes, CALCA (

Indexed as

AdultAgedAnimalsCalcitonin Gene-Related PeptideCarcinoma, Pancreatic DuctalCpG IslandsDisease Models, AnimalDNA MethylationFemaleHumansMaleMiddle AgedPancreatic NeoplasmsPromoter Regions, GeneticProto-Oncogene Proteins c-aktRatsCALCA protein, humanCALCB protein, humanCalcitonin Gene-Related PeptideProto-Oncogene Proteins c-akt

Identifiers

PMID34394823
PMCPMC8357496
OpenAlexW3193118075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.