Evidence map›Paper›PMID 34394777›Full record

ArticleCanadian respiratory journal2021

Increased Proportion of Dual-Positive Th2-Th17 Cells Promotes a More Severe Subtype of Asthma.

Wenjin Sun, Yu Yuan, Lulu Qiu, Qingping Zeng, Jingsi Jia, Xudong Xiang, Aijun Jia, Libing Ma, Shaokun Liu, Bing Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. TThe Journal of allergy and clinical immunology · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenjin SunDepartment of General Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.ORCID 0000-0002-1124-1550
Yu YuanDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Lulu QiuDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Qingping ZengDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Jingsi JiaDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Xudong XiangDepartment of Emergency, The Second Xiangya Hospital of Central South University, Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan 410011, China.ORCID 0000-0003-4707-7809
Aijun JiaDepartment of Respiratory Medicine, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.
Libing MaDepartment of Respiratory Medicine, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China.
Shaokun LiuDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.ORCID 0000-0002-9839-2342
Bing XiaoDepartment of Emergency, The Second Xiangya Hospital of Central South University, Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan 410011, China.ORCID 0000-0001-6572-5641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is a heterogeneous disease, and abnormal activation of T cells is the driving link of asthma's pathophysiological changes. Dual-positive Th2-Th17 cells, as newly discovered T-helper cells, have the functions of Th2 and Th17 cells and can coproduce Th2 and Th17 cytokines. Previous studies have shown that dual-positive Th2-Th17 cells increase the chances of asthma and correlate with asthma severity. However, the exact role of dual-positive Th2-Th17 cells in asthma is not known. Since there is no mature differentiation method for dual-positive Th2-Th17 cells, the present study aimed to clarify the strict differentiation conditions and reveal how dual-positive Th2-Th17 cells regulate asthma phenotypes. In this study, we confirmed that IL-1

Indexed as

AnimalsAsthmaCell DifferentiationCytokinesMiceTh17 CellsTh2 CellsCytokines

Identifiers

PMID34394777
PMCPMC8363460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.