Evidence map›Paper›PMID 34394751›Full record

ArticlePolymer chemistry2021

Synthetic Approaches for Copolymers Containing Nucleic Acids and Analogues: Challenges and Opportunities.

Hao Lu, Jiansong Cai, Ke Zhang

Abstract read
In one paragraph

Article in Polymer chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hao LuDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Jiansong CaiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.
Ke ZhangDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA.

Funding

Making Oligonucleotides Better Biopharmaceuticals by Steric ProtectionR01GM121612 · NIGMS · NORTHEASTERN UNIVERSITY · PI Ke Zhang · 2017 to 2026
$3.7M
Targeting Oncogenic KRAS with Brush-Architectured Poly(ethylene glycol)-DNA ConjugatesR01CA251730 · NCI · NORTHEASTERN UNIVERSITY · PI ZHANG, KE · 2020 to 2024
$1.9M
NCI NIH HHS R01 CA251730NIGMS NIH HHS R01 GM121612
6 · The paper itself

Abstract

A deep integration of nucleic acids with other classes of materials have become the basis of many useful technologies. Among these biohybrids, nucleic acid-containing copolymers has seen rapid development in both chemistry and application. This review focuses on the various synthetic approaches to access nucleic acid-polymer biohybrids spanning post-polymerization conjugation, nucleic acids in polymerization, solid-phase synthesis, and nucleoside/nucleobase-functionalized polymers. We highlight the challenges associated with working with nucleic acids with each approach and the ingenuity of the solutions, with the hope of lowering the entry barrier and inpsiring further investigations in this exciting area.

Identifiers

PMID34394751
PMCPMC8356553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.