Evidence map›Paper›PMID 34394718›Full record

ArticleObstetric medicine2021

Mechanical heart valves and pregnancy: Issues surrounding anticoagulation. Experience from two obstetric cardiac centres.

Francois Dos Santos, Lucia Baris, Alice Varley, Jerome Cornette, Joanna Allam, Philip Steer, Lorna Swan, Michael Gatzoulis, Jolien Roos-Hesselink, Mark R Johnson

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PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetric medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanical heart valves and pregnancy.JRSM cardiovascular disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Francois Dos SantosDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-9301-8397
Lucia BarisDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Alice VarleyDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Jerome CornetteDepartment of Obstetric Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Joanna AllamDepartment of Anaesthesia, Chelsea and Westminster Hospital, London, UK.
Philip SteerDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Lorna SwanDepartment of Cardiology, Toronto General Hospital, Toronto, Canada.
Michael GatzoulisDepartment of Cardiology, Royal Brompton Hospital, London, UK.
Jolien Roos-HesselinkDepartment of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Mark R JohnsonDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Imperial College London · GBErasmus MC · NLChelsea and Westminster Hospital · GBRoyal Brompton Hospital · GBToronto General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnant women with mechanical heart valves are at significant risk of obstetric/cardiac complications. This study compares the anticoagulation management in two obstetric cardiac centres.

methodsRetrospective case-note review from Chelsea and Westminster/Royal Brompton Hospitals (CR) and Erasmus Medical Centre (EMC). Main outcome measure was mechanical heart valve thrombosis.

resultsNineteen pregnancies from CR and 25 pregnancies from EMC were included. Most women were on low-molecular-weight heparin (LMWH) throughout pregnancy at CR, whereas at EMC most had LMWH in the first trimester and vitamin K antagonists in subsequent trimesters. Peak anti-factor Xa were performed monthly at CR, levels 0.39-1.51 IU/mL (mean 0.82 IU/mL). Anticoagulation management peri-partum was inconsistent. Delivery was mainly by caesarean section at CR (74%) and vaginal delivery at EMC (64%). No maternal deaths and only one mechanical heart valve thrombosis at CR. Two mechanical heart valve thromboses and one maternal death at EMC.

conclusionPeri-partum anticoagulation strategies, anticoagulation monitoring and mode of delivery inconsistencies reported.

Indexed as

anticoagulationheart valve diseasesHigh-risk pregnancymechanical heart valvepregnancy complications

Identifiers

PMID34394718
PMCPMC8358247
OpenAlexW3033649788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.