Evidence map›Paper›PMID 34394712›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2021

Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets.

Chenghu Huang, Pan Lei, Caibi Peng, Min Li, Yifei Guo, Xuefeng Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Berberine Inhibits Dengue Virus through Dual Mechanisms.Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chenghu HuangDepartment of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.ORCID https://orcid.org/0000-0001-7088-1753
Pan LeiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.
Caibi PengDepartment of Endocrinology, Bishan Hospital of Chongqing, Bishan, Chongqing 402760, China.
Min LiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.
Yifei GuoDepartment of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.
Xuefeng LiDepartment of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.ORCID https://orcid.org/0000-0003-2033-7535
Guiyang Medical University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

resultsProlonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal

conclusionsWe demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress.

Indexed as

BerberineIslets of LangerhansAnimalsAutophagyMiceMice, KnockoutPeptidyl-Dipeptidase ARenin-Angiotensin SystemStress, PhysiologicalBerberinePeptidyl-Dipeptidase A

Identifiers

PMID34394712
PMCPMC8356011
OpenAlexW3190010399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.