ArticleAfrican health sciences2020
The relationship between Vitamin D deficiency and polycystic ovary syndrome.
Article in African health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of vitamin D supplementation on metabolic parameters in women with polycystic ovary syndrome: a randomized controlled trial.Journal of ovarian research · 2024Trial
- Relationship between thyroid-stimulating hormone levels and the severity of vitamin D deficiency by age group.Clinical and experimental reproductive medicine · 2025Article
- Characterizing Genetic, Epigenetic, Nutritional, and Clinico-Biochemical Profile of Women With Polycystic Ovary Syndrome: A Case-Control Study.Journal of nutrition and metabolism · 2025Article
- Metabolic and hormonal profiling in polycystic ovarian syndrome: insights into INSR gene variations.Molecular biology reports · 2024Article
- Women's fertility and vitamin D: Could hypovitaminosis D biomarkers correlate with the disease, and explain the unexplained female factor infertility?African health sciences · 2024Article
- Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome.Clinical and experimental reproductive medicine · 2024Article
- Vitamin D levels and lipid profiles in patients with polycystic ovary syndrome.BMC women's health · 2024Article
- Association of rs4588 polymorphism in vitamin D binding protein gene with polycystic ovarian syndrome in Iranian women: a case-control study.BMC research notes · 2024Article
- PCOS and vitamin D: a clinical appraisal.Archives of gynecology and obstetrics · 2024Review
- Role of VDR gene polymorphisms and vitamin D levels in normal and overweight patients with PCOS.Journal of genetics · 2024Article
- Vitamin D and Cardiovascular Diseases: An Update.Cureus · 2023Review
- Vitamin D3 and its necessity for health.Annals of medicine and surgery (2012) · 2022Article
- Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis.Biomedicines · 2021Review
- Editor's choice: this December 2020.African health sciences · 2020Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D deficiency in complex PCOS pathophysiological pathways.
methodsTwo hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency, and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and thyroid function tests) were compared between the two groups.
resultsEighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically significantly higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group 1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=-0.459), serum testosterone (r =-0.374) and dehydroepiandrosterone-sulfate levels (r=-0.418); (all; p< 0.05).
conclusionThe study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.
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