ArticleFrontiers in genetics2021
DNA Methylation as a Marker of Body Shape in Premenopausal Women.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Tissue-specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements.Aging cell · 2025Article
- Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing.American journal of physiology. Cell physiology · 2024Article
- Article
- An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells.International journal of molecular sciences · 2023Article
- Blood-based genome-wide DNA methylation correlations across body-fat- and adiposity-related biochemical traits.American journal of human genetics · 2023Article
- Adipose 'neighborhoods' collaborate to maintain metabolic health.Current opinion in genetics & development · 2023Review
- Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells.Genes & development · 2022Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Preferential accumulation of fat in the gluteo-femoral (GF) depot (pear shape) rather than in the abdominal (A) depot (apple shape), protects against the development of metabolic diseases but the underlying molecular mechanism is still unknown. Recent data, including our work, suggest that differential epigenetic marking is associated with regulation of genes attributed to distinct fat distribution. Here, we aimed to compare the genomic DNA methylation signatures between apple and pear-shaped premenopausal women. To investigate the contribution of upper and lower body fat, we used paired samples of A-FAT and GF-FAT, analyzed on the BeadChip Methylation Array and quantified the differentially methylated sites between the 2 groups of women. We found unique DNA methylation patterns within both fat depots that are significantly different depending on the body fat distribution. Around 60% of the body shape specific DNA methylation sites identified in adipose tissue are maintained
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.