Evidence map›Paper›PMID 34394125›Full record

ReviewFrontiers in immunology2021

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction.

Marie-Pierre Piccinni, Raj Raghupathy, Shigeru Saito, Julia Szekeres-Bartho

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05473273 recruitingnot on this mapstarted 2023, after this paper: background citation

Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle (NC).

TypeobservationalSponsorART Fertility Clinics LLCRan2023 to 2026Enrolled40ConditionsInfertility, FemaleArmsEndometrin 100Mg Vaginal Insert, Estradiol Valerate
NCT07120958 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

What Impact Does Uterine Immunity Have on the Success of Euploid Thawed Embryos?

TypeobservationalSponsorMomo FertilifeRan2025 to 2026Enrolled30ConditionsInfertility Assisted Reproductive Technology
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
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  18. Stress, Well-Being, and Reproduction in Wildlife.Advances in experimental medicine and biology · 2026
    Review
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Marie-Pierre PiccinniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Raj RaghupathyDepartment of Microbiology, Faculty of Medicine, Kuwait University, Kuwait, Kuwait.
Shigeru SaitoDepartment of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Julia Szekeres-BarthoDepartment of Medical Biology, Medical School, Pecs University, Pecs, Hungary.
Kuwait University · KWUniversity of Florence · ITUniversity of Pecs · HUUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal immune system. Several protective mechanisms operate during gestation to correct the harmful effects of anti-fetal immunity and to support a healthy pregnancy outcome. Pregnancy is characterized by gross alterations in endocrine functions. Progesterone is indispensable for pregnancy and humans, and it affects immune functions both directly and

Indexed as

AnimalsCytokinesDietary SupplementsDydrogesteroneFemaleGene Expression RegulationHormonesHumansImmunomodulationMaternal-Fetal ExchangePregnancyProgesteroneReproductionSignal TransductionT-Lymphocyte SubsetsCytokinesDydrogesteroneHormonesProgesteronecytokinesprogesteroneregulatory T cellsTh 17 cellTh2 dominance

Identifiers

PMID34394125
PMCPMC8355694
OpenAlexW3183642905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.