Evidence map›Paper›PMID 34394112›Full record

ArticleFrontiers in immunology2021

Longitudinal Analysis of Dengue Virus-Specific Memory T Cell Responses and Their Association With Clinical Outcome in Subsequent DENV Infection.

Luis Alberto Sanchez-Vargas, Kathryn B Anderson, Anon Srikiatkhachorn, Jeffrey R Currier, Heather Friberg, Timothy P Endy, Stefan Fernandez, Anuja Mathew, Alan L Rothman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges.Current topics in microbiology and immunology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Mucosal Vaccination: A Promising Alternative Against Flaviviruses.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Luis Alberto Sanchez-VargasDepartment of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, RI, United States.
Kathryn B AndersonDepartment of Medicine, Department of Microbiology and Immunology, Institute for Global Health and Translational Sciences, State University of New York-Upstate Medical University, Syracuse, NY, United States.
Anon SrikiatkhachornDepartment of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, RI, United States.
Jeffrey R CurrierViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Heather FribergViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Timothy P EndyDepartment of Medicine, Department of Microbiology and Immunology, Institute for Global Health and Translational Sciences, State University of New York-Upstate Medical University, Syracuse, NY, United States.
Stefan FernandezDepartment of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Anuja MathewDepartment of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, RI, United States.
Alan L RothmanDepartment of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island, Providence, RI, United States.
Providence College · USSUNY Upstate Medical University · USWalter Reed Army Institute of Research · USArmed Forces Research Institute of Medical Science · THKing Mongkut's Institute of Technology Ladkrabang · THUniversity of Rhode Island · US

Funding

VIRAL DETERMINANTS OF SEVERE DENGUE DISEASEP01AI034533 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ROTHMAN, ALAN L · 1994 to 2022
$42.0M
Statistics and Data Management P20GM104317 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI MICHELOW, IAN · 2013 to 2017
$9.8M
NIAID NIH HHS P01 AI034533NIGMS NIH HHS P20 GM104317
6 · The paper itself

Abstract

Memory T cells resulting from primary dengue virus (DENV) infection are hypothesized to influence the clinical outcome of subsequent DENV infection. However, the few studies involving prospectively collected blood samples have found weak and inconsistent associations with outcome and variable temporal trends in DENV-specific memory T cell responses between subjects. This study used both

Indexed as

AdolescentChildCytokinesDengueDengue VirusFemaleHumansLongitudinal StudiesMaleMemory T CellsSeverity of Illness IndexCytokinescultured ELISpot assayscytokine - immunological termsdengue (DENV)interferon-gamma (IFN) and tumor necrosis factor-alpha (TNF)memory T cell analysis

Identifiers

PMID34394112
PMCPMC8355709
OpenAlexW3185981320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.