Evidence map›Paper›PMID 34394070›Full record

ArticleFrontiers in immunology2021

Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity.

Utpal Kumar Adhikari, Elif Sakiz, Xian Zhou, Umma Habiba, Sachin Kumar, Meena Mikhael, Matteo Senesi, Chun Guang Li, Gilles J Guillemin, Lezanne Ooi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Utpal Kumar AdhikariSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Elif SakizSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Xian ZhouNational Institute of Complementary Medicine (NICM) Health Research Institute, Western Sydney University, Campbelltown, NSW, Australia.
Umma HabibaSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Sachin KumarSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Meena MikhaelSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Matteo SenesiAustralian National Creutzfeldt-Jakob Disease Registry, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Chun Guang LiNational Institute of Complementary Medicine (NICM) Health Research Institute, Western Sydney University, Campbelltown, NSW, Australia.
Gilles J GuilleminDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Wollongong, NSW, Australia.
Lezanne OoiSchool of Chemistry and Molecular Bioscience, Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Monique Antoinette DavidSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Steven CollinsAustralian National Creutzfeldt-Jakob Disease Registry, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Tim KarlSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Mourad TayebiSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
Western Sydney University · AUCamden and Campbelltown Hospitals · AUFlorey Institute of Neuroscience and Mental Health · AUIllawarra Health and Medical Research Institute · AUMacquarie University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous reports identified proteins associated with 'apoptosis' following cross-linking PrP Methods: Initially, we predicted the allergenicity of the epitope sequences associated with 'neurotoxic' anti-PrP antibodies using allergenicity prediction servers. We then investigated whether anti-PrP antibody treatment of mouse primary neurons (MPN), neuroblastoma cells (N2a) and microglia (N11) cell lines lead to a neuronal allergenic response. Results: Conclusions: This study showed for the first time that anti-PrP antibody binding to PrP

Indexed as

AnimalsAntibodiesEpitopes, B-LymphocyteHumansHypersensitivityMiceNeurogliaNeuronsPrPC ProteinsAntibodiesEpitopes, B-LymphocytePrPC Proteinsallergenicityanti-PrP antibodiescellular prion proteinmicroglia cell linemouse primary neuronsneuroblastoma cell lineneurotoxicity

Identifiers

PMID34394070
PMCPMC8361482
OpenAlexW3189245340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.