Evidence map›Paper›PMID 34394059›Full record

ArticleFrontiers in microbiology2021

The EcoCyc Database in 2021.

Ingrid M Keseler, Socorro Gama-Castro, Amanda Mackie, Richard Billington, César Bonavides-Martínez, Ron Caspi, Anamika Kothari, Markus Krummenacker, Peter E Midford, Luis Muñiz-Rascado and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
32.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 227 citations in OpenAlex.

  1. Article
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  5. Article
  6. SeaB is a conservedInfection and immunity · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Bacterial iron acquisition byProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. The EcoCyc database (2025).EcoSal Plus · 2025
    Review
  19. Genome-wide Screening of the Escherichia coli Keio Knockout Collection Identifies Genetic Determinants of Epetraborole Hypersusceptibility.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Ingrid M KeselerBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Socorro Gama-CastroCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Amanda MackieDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Richard BillingtonBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
César Bonavides-MartínezCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Ron CaspiBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Anamika KothariBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Markus KrummenackerBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Peter E MidfordBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Luis Muñiz-RascadoCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Wai Kit OngBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Suzanne PaleyBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Alberto Santos-ZavaletaCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Pallavi SubhravetiBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Víctor H TierrafríaCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Alan J WolfeDepartment of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States.
Julio Collado-VidesCentro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, México.
Ian T PaulsenDepartment of Molecular Sciences, Macquarie University, Sydney, NSW, Australia.
Peter D KarpBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
SRI International · USUniversidad Nacional Autónoma de México · MXMacquarie University · AUBoston University · USLoyola University Chicago · US

Funding

The EcoCyc Model Organism Database for Escherichia coli [SRI Proposal ECU 14-631]U24GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2006 to 2018
$12.3M
The EcoCyc Model Organism Database for Escherichia coliR01GM077678 · NIGMS · SRI INTERNATIONAL · PI KARP, PETER D · 2019 to 2022
$4.6M
HIGH THROUGHPUT LITERATURE CURATION OF GENETIC REGULATION IN BACTERIAL MODELSR01GM110597 · NIGMS · CENTER FOR GENOMIC SCIENCES · PI COLLADO-VIDES, JULIO · 2015 to 2018
$1.6M
NIGMS NIH HHS R01 GM077678NIGMS NIH HHS R01 GM110597NIGMS NIH HHS U24 GM077678
6 · The paper itself

Abstract

The EcoCyc model-organism database collects and summarizes experimental data for

Indexed as

drug efflux transportersEcoCycEscherichia coligene regulationmetabolismmodel-organism database

Identifiers

PMID34394059
PMCPMC8357350
OpenAlexW3185730212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.