ArticleFrontiers in microbiology2021
Prenatal Depression, Breastfeeding, and Infant Gut Microbiota.
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From Mind to Milk: The Influence of Psychological Factors on the Composition of Human Breast Milk.Nutrients · 2025Pooled it
- Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Breastfeeding in the Context of Trauma and Previous Psychological Experiences: A Narrative Review.Nutrients · 2026Review
- Does preeclampsia impact the gut microbiota of preterm offspring during early infancy?Journal of translational medicine · 2025Article
- Unraveling the Triad: A Bioinformatics Analysis of the Interplay between Prenatal Depression, Inflammation, and the Gut Microbiota.CNS & neurological disorders drug targets · 2025Article
- Integrative Analysis of the Impact of Prenatal Depression on the Newborn Intestinal Microbiota.Central nervous system agents in medicinal chemistry · 2025Article
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- Impact of the gut microbiota-Th17 cell axis on inflammatory depression.Frontiers in psychiatry · 2024Review
- Selective serotonin reuptake inhibitors during pregnancy and lactation: A scoping review of effects on the maternal and infant gut microbiome.Developmental psychobiology · 2024Article
- Infants exposedmSphere · 2023Article
- Scarring the early-life microbiome: its potential life-long effects on human health and diseases.BMB reports · 2023Review
- Maternal breastfeeding is associated with offspring microbiome diversity; a secondary analysis of the MicrobeMom randomized control trial.Frontiers in microbiology · 2023Article
- Assessment of human milk in the era of precision health.Current opinion in clinical nutrition and metabolic care · 2022Review
- Cross-talk between the infant/maternal gut microbiota and the endocrine system: a promising topic of research.Microbiome research reports · 2022Article
- MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depressive symptoms are common during pregnancy and are estimated to affect 7-20% of pregnant women, with higher prevalence found in those with a prior history of depression, in ethnic minorities, and those with increased exposure to stressful life events. Maternal depression often remains undiagnosed, and its symptoms can increase adverse health risks to the infant, including impaired cognitive development, behavioral problems, and higher susceptibility to physical illnesses. Accumulating research evidence supports the association between maternal physical health elements to infant gut health, including factors such as mode of delivery, medication, feeding status, and antibiotic use. However, specific maternal prenatal psychosocial factors and their effect on infant gut microbiota and immunity remains an area that is not well understood. This article reviews the literature and supplements it with new findings to show that prenatal depression alters: (i) gut microbial composition in partially and fully formula-fed infants at 3-4 months of age, and (ii) gut immunity (i.e., secretory Immunoglobulin A) in all infants independent of breastfeeding status. Understanding the implications of maternal depression on the infant gut microbiome is important to enhance both maternal and child health and to better inform disease outcomes and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.