Evidence map›Paper›PMID 34394003›Full record

ArticleFrontiers in endocrinology2021

Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.

Anna Goddi, Alanis Carmona, Liesl Schroedl, Jeremy M White, Matthew J Piron, Avelino De Leon, Isabel Casimiro, Alexandria Hoffman, Maria A Gonzalez Porras, Eric M Brey and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anna GoddiCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
Alanis CarmonaSection of Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL, United States.
Liesl SchroedlPritzker School of Medicine, The University of Chicago, Chicago, IL, United States.
Jeremy M WhiteCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
Matthew J PironSection of Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL, United States.
Avelino De LeonCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
Isabel CasimiroSection of Endocrinology, Diabetes, and Metabolism, The University of Chicago, Chicago, IL, United States.
Alexandria HoffmanCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
Maria A Gonzalez PorrasDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, United States.
Eric M BreyDepartment of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, United States.
Matthew J BradyCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
Ronald N CohenCommittee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL, United States.
University of Chicago · USThe University of Texas at San Antonio · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
INTERGRATED CLINICAL AND BASIC ENDOCRINOLOGY RESEARCHT32DK007011 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 1986 to 2026
$5.8M
Circadian Genes and Adipose Function: Impact of Chronotype, Obesity and RaceR01DK103014 · NIDDK · UNIVERSITY OF CHICAGO · PI BRADY, MATTHEW J · 2014 to 2018
$2.2M
The Role of Extracellular Environment in Adipocyte FateF32DK122754 · NIDDK · UNIVERSITY OF TEXAS SAN ANTONIO · PI GONZALEZ PORRAS, MARIA ALEJANDRA · 2020 to 2022
$217k
NIDDK NIH HHS F32 DK122754NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK103014NIDDK NIH HHS T32 DK007011
6 · The paper itself

Abstract

Obesity affects nearly one billion globally and can lead to life-threatening sequelae. Consequently, there is an urgent need for novel therapeutics. We have previously shown that laminin, alpha 4 (

Indexed as

AdultAnimalsCells, CulturedDisease Models, AnimalFemaleHumansLamininMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedObesityUp-RegulationYoung AdultLAMA4 protein, humanLama4 protein, mouseLamininadipose tissuebasement membraneextracellular matrixlamininsmetabolic diseaseobesity

Identifiers

PMID34394003
PMCPMC8355986
OpenAlexW3185058807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.