ArticleFrontiers in endocrinology2021
Perfluoroalkyl Substance Exposure and the BDNF Pathway in the Placental Trophoblast.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life.Toxics · 2023Review
- Article
- Screening cell-cell communication in spatial transcriptomics via collective optimal transport.Nature methods · 2023Article
- Pro- and anti-inflammatory cytokines and growth factors in patients undergoingFrontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that have become globally ubiquitous in humans and the environment. Methods: The expression and localization of BDNF receptors-p75 Results: In first trimester human placentas, TrkB and p75 Conclusions: BDNF receptors are present in different regions of human placental villi, indicating diverse functions of BDNF signaling in placental development. Our findings suggest that the BDNF pathway in placental trophoblast cells is not disrupted by exposures to PFOS, PFOA, PFBS, and a PFAS mixture, but may be affected by PFNA exposures. Further investigation is needed on how PFAS affects other critical signaling pathways during fetal neurodevelopment.
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Registered trials
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