ArticleFrontiers in psychiatry2021
Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Epigenome-wide association study meta-analysis of wellbeing.Clinical epigenetics · 2026Pooled it
- Paediatric DNA methylation profile scores: a systematic review and open-source atlas.EBioMedicine · 2026Pooled it
- Interactions between nutrition and the epigenome: how can it be harnessed for public health?Future science OA · 2026Article
- DNA methylation as proxy of genetic, prenatal and perinatal psychiatric risk factors.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetics of Childhood Obesity.Hormone research in paediatrics · 2026Review
- Risk factors and prediction for pediatric obesity: current status and future perspectives.Endocrine journal · 2025Review
- Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.PloS one · 2025Article
- Nonshared environment: Real but random.JCPP advances · 2024Article
- Challenges and perspectives in computational deconvolution of genomics data.Nature methods · 2024Review
- Pruning and thresholding approach for methylation risk scores in multi-ancestry populations.Epigenetics · 2023Article
- Genetics and Epigenetics in Obesity: What Do We Know so Far?Current obesity reports · 2023Review
- Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations.Environmental health perspectives · 2023Review
- A novel approach to risk exposure and epigenetics-the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health.BMC medicine · 2023Article
- Using epigenomics to understand cellular responses to environmental influences in diseases.PLoS genetics · 2023Review
- Epigenetics and the Exposome: DNA Methylation as a Proxy for Health Impacts of Prenatal Environmental Exposures.Exposome · 2023Article
- A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events.Clinical epigenetics · 2022Article
- Integration of Genomic Risk Scores to Improve the Prediction of Childhood Asthma Diagnosis.Journal of personalized medicine · 2022Article
- Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood.Frontiers in genetics · 2022Article
- Epigenome-wide association studies: current knowledge, strategies and recommendations.Clinical epigenetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may be seen as the epigenetic equivalent of PGS, but because of their dynamic nature and sensitivity of non-genetic exposures may add to complex trait prediction independently of PGS. MS and PGS were calculated based on genotype data and DNA-methylation data in blood samples from adults (Illumina 450 K;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.