Evidence map›Paper›PMID 34393849›Full record

ArticleFrontiers in psychiatry2021

Association Between Abundance of

Cuizhen Zhu, Mingming Zheng, Usman Ali, Qingrong Xia, Zhongxian Wang, Chenlong, Lihui Yao, Yuanyuan Chen, Junwei Yan, Keming Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  7. Gut microbiota: contributing to high CVD prevalence in people living with schizophrenia?European archives of psychiatry and clinical neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Cuizhen ZhuDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Mingming ZhengDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Usman AliShanghai key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qingrong XiaDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Zhongxian WangDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
ChenlongDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Lihui YaoDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Yuanyuan ChenDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Junwei YanDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Keming WangDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Jinghong ChenShanghai key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xulai ZhangDepartment of Science and Education, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Anhui Mental Health Center · CNAnhui Medical University · CNShanghai Jiao Tong University · CNShanghai Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence indicates an interaction between dysbiosis of the microbiota and the pathogenesis of schizophrenia. However, limited information is available on the specific microbial communities associated with symptoms of schizophrenia. Therefore, this study aimed to investigate gut microbiota dysbiosis and its relationship with psychopathologies in schizophrenia. We recruited 126 participants and divided them into three groups according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria-acute group (patients with acute schizophrenia), remission group (patients with schizophrenia in remission), and control group (healthy controls). Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale. Microbiota compositions, diversity and community structure were evaluated using 16S rRNA sequencing. Pearson's correlation analysis was used to evaluate the association between bacterial taxa and psychotic symptoms. The beta-diversity of microbiota composition in the acute group was distinct from that in the remission and control groups (PC1 = 21.11% vs. PC2 = 12.86%,

Indexed as

16Sr RNA sequencinggut microbiotanegative symptompositive and negative syndrome scaleschizophrenia

Identifiers

PMID34393849
PMCPMC8362742
OpenAlexW3193344663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.