Evidence map›Paper›PMID 34393823›Full record

ArticleFrontiers in physiology2021

Deep Learning Classification of Unipolar Electrograms in Human Atrial Fibrillation: Application in Focal Source Mapping.

Shun Liao, Don Ragot, Sachin Nayyar, Adrian Suszko, Zhaolei Zhang, Bo Wang, Vijay S Chauhan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Convolutional neural network for real‑time localization of ganglionated plexi from bipolar intracardiac electrograms.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  2. Article
  3. Review
  4. Atrial fibrillation in continuous flow-left ventricular assist device (CF-LVAD) patients: impact on pathophysiology.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  5. Review
  6. State of the Art of Artificial Intelligence in Clinical Electrophysiology in 2025: A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), and the ESC Working Group on E-Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  11. Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  12. [Developments of ex vivo cardiac electrical mapping and intelligent labeling of atrial fibrillation substrates].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Review
  13. Review
  14. Machine learning in the detection and management of atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Review
  15. Article
  16. AI in the EP lab - mapping, imaging, and signal interpretation.Indian pacing and electrophysiology journal
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shun LiaoPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Don RagotPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Sachin NayyarPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Adrian SuszkoPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Zhaolei ZhangDepartment of Computer Science, University of Toronto, Toronto, ON, Canada.
Bo WangPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
Vijay S ChauhanPeter Munk Cardiac Centre, Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada.
University Health Network · CAToronto General Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Focal sources are potential targets for atrial fibrillation (AF) catheter ablation, but they can be time-consuming and challenging to identify when unipolar electrograms (EGM) are numerous and complex. Our aim was to apply deep learning (DL) to raw unipolar EGMs in order to automate putative focal sources detection. We included 78 patients from the Focal Source and Trigger (FaST) randomized controlled trial that evaluated the efficacy of adjunctive FaST ablation compared to pulmonary vein isolation alone in reducing AF recurrence. FaST sites were identified based on manual classification of sustained periodic unipolar QS EGMs over 5-s. All periodic unipolar EGMs were divided into training (

Indexed as

atrial fibrillationcatheter ablationfocal sourcesmachine learningunipolar electrogram

Identifiers

PMID34393823
PMCPMC8360838
OpenAlexW3187907849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.