ArticleAdvanced functional materials2021
Detailed Balance Broken by Catch Bond Kinetics Enables Mechanical-Adaptation in Active Materials.
Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- State-dependent energy conversion produces degenerate dissipation in active actomyosin networks.bioRxiv : the preprint server for biology · 2026Article
- De novo DNA-based catch bonds.Nature chemistry · 2024Article
- Catch bond kinetics are instrumental to cohesion of fire ant rafts under load.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Catch bond-inspired hydrogels with repeatable and loading rate-sensitive specific adhesion.Bioactive materials · 2023Article
- F-actin architecture determines constraints on myosin thick filament motion.Nature communications · 2022Article
- Understanding cytoskeletal avalanches using mechanical stability analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Treadmilling and dynamic protrusions in fire ant rafts.Journal of the Royal Society, Interface · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Unlike nearly all engineered materials which contain bonds that weaken under load, biological materials contain "catch" bonds which are reinforced under load. Consequently, materials, such as the cell cytoskeleton, can adapt their mechanical properties in response to their state of internal, non-equilibrium (active) stress. However, how large-scale material properties vary with the distance from equilibrium is unknown, as are the relative roles of active stress and binding kinetics in establishing this distance. Through course-grained molecular dynamics simulations, the effect of breaking of detailed balance by catch bonds on the accumulation and dissipation of energy within a model of the actomyosin cytoskeleton is explored. It is found that the extent to which detailed balance is broken uniquely determines a large-scale fluid-solid transition with characteristic time-reversal symmetries. The transition depends critically on the strength of the catch bond, suggesting that active stress is necessary but insufficient to mount an adaptive mechanical response.
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Registered trials
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