ArticleBioinformation2021
Cytotoxic, antioxidant, and antimicrobial activities of Celery (Apium graveolens L.).
Article in Bioinformation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Developing a plant based hand sanitizer using antibacterial Apium graveolens leaf extract.Scientific reports · 2025Article
- Phytochemical-assisted synthesis, optimization, and characterization of silver nanoparticles for antimicrobial activity.RSC advances · 2025Article
- Article
- Antioxidant Potentials, Protease Inhibitory, and Cytotoxic Activities of Various Isolated Extracts from Salvia aegyptiaca.Iranian biomedical journal · 2025Article
- Exosomal Delivery Enhances the Antiproliferative Effects of Acid-HydrolyzedFoods (Basel, Switzerland) · 2024Article
- Cardiovascular Effects of Herbal Products and Their Interaction with Antihypertensive Drugs-Comprehensive Review.International journal of molecular sciences · 2024Review
- Biofortification and Valorization of Celery byproducts Using Selenium and PGPB under Reduced Nitrogen Regimes.Foods (Basel, Switzerland) · 2024Article
- Enhanced antioxidant phytochemicals and catalase activity of celery by-products by a combined strategy of selenium and PGPB under restricted N supply.Frontiers in plant science · 2024Article
- System Pharmacological Approach to Investigate and Validate Multitargeted and Therapeutic Effect of Furocoumarins ofAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Development of a Polyherbal Topical Gel for the Treatment of Acne.Gels (Basel, Switzerland) · 2023Article
- Review
- Root Vegetables-Composition, Health Effects, and Contaminants.International journal of environmental research and public health · 2022Review
- Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits.Evidence-based complementary and alternative medicine : eCAM · 2022Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celery (Apium graveolens Linn, Family: Apiaceae) is a common edible herb used as a spice in the traditional medicine of several nations since time immemorial. The whole plant is extensively used in cooking as soups and salads. A. graveolens has various pharmacological properties such as anticancer, anti-obesity, anti-hepatotoxic, and antihypertensive agents. Hence, it is of interest to document the in vitro cytotoxic, antioxidant, and antimicrobial activity of A. graveolens. The plants were collected in the local market, shade dried, and different parts of the plants were extracted with 70% ethanol using a cold maceration process. Antioxidant tests were performed based on the various radical scavenging methods. Antimicrobial activity and MIC were completed using the respective cup-plate and two-fold serial dilution method. In vitro cytotoxic studies were achieved by the MTT; Sulphorhodamine B assayed total cell protein content. DLA and ESC cells determined the short-term toxicity. The leaf extract exhibited significant antioxidant properties against NO, DPPH, ABTS, LPO, and HPO methods. Thus, potential inhibition against Gram-positive, Gram-negative, and fungal strains within the MIC ranges of 250-500 µg/ml was observed. All the extracts of the plant presented in the study revealed greater cytotoxicity effects against five respective cancer cell lines, L6, Vero, BRL 3A, A-549, L929, and L-929 with the ranging of 443-168.5 µg/ml. Thus, we show that A. graveolens possess a potential cytotoxic, antioxidant, and antimicrobial activity.
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