Evidence map›Paper›PMID 34393171›Full record

ReviewInternal medicine (Tokyo, Japan)2022

Bilateral Adrenal Infarctions as an Initial Manifestation of TAFRO Syndrome: A Case Report and Review of the Literature.

Shun Yonezaki, Kazuya Nagasaki, Hiroyuki Yamaguchi, Hiroyuki Kobayashi

Abstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Expert Perspective: Diagnosis and Treatment of Castleman Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2026
    Review
  3. TAFRO Syndrome with Massive Bilateral Adrenal Hemorrhage.Internal medicine (Tokyo, Japan) · 2025
    Article
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  5. TAFRO subtype of idiopathic multicentric Castleman disease in a 22-year-old man.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. COVID-19 infection: from stress-related cortisol levels to adrenal glands infarction.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shun YonezakiDepartment of Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, Japan.
Kazuya NagasakiDepartment of Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, Japan.
Hiroyuki YamaguchiDepartment of Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, Japan.
Hiroyuki KobayashiDepartment of Internal Medicine, Mito Kyodo General Hospital, University of Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TAFRO syndrome is a systemic inflammatory disorder resembling multicentric Castleman disease; it is characterized by thrombocytopenia, anasarca, a fever, reticulin fibrosis, and organomegaly. Involvement of the adrenal glands, including adrenal infarction, hemorrhaging, and adrenomegaly, has recently been reported in several cases and been considered a characteristic early-stage symptom. We herein report a case of TAFRO syndrome initially presenting with bilateral adrenal infarctions and review the literature on TAFRO syndrome related to adrenal involvement. This case suggests that adrenal abnormalities as an early clinical feature of TAFRO syndrome may be useful for the early diagnosis.

Indexed as

Adrenal Gland DiseasesCastleman DiseaseThrombocytopeniaEdemaHumansInfarctionadrenal hemorrhagingadrenal infarctionTAFRO syndrome

Identifiers

PMID34393171
PMCPMC8943364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.