Evidence map›Paper›PMID 34393157›Full record

ArticleThe Journal of reproduction and development2021

Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X.

Kai-Yi Sun, Shi-Meng Guo, Gui-Ping Cheng, Ying Yin, Ximiao He, Li-Quan Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. The multi-omics regulatory landscape of human early embryogenesis.Cellular and molecular life sciences : CMLS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kai-Yi SunInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Shi-Meng GuoInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Gui-Ping ChengInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Ying YinSchool of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Ximiao HeSchool of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Li-Quan ZhouInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei 430030, China.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During mammalian preimplantation development, stimulation of zygotic genome activation (ZGA) and transposable elements (TEs) shapes totipotency profiling. A rare mouse embryonic stem cells (mESCs) subpopulation is capable of transiently entering a state resembling 2-cell stage embryos, with subtypes of TEs expressed and ZGA genes transiently activated. In this study, we found that deletion of H2A.X in mESCs led to a significant upregulation of ZGA genes and misregulated TEs. ChIP-seq analysis indicated a direct association of H2A.X at the Dux locus for silencing the Dux gene and its downstream ZGA genes in mESCs. We also demonstrated that histone variant H2A.X is highly enriched in human cleavage embryos when ZGA genes and TEs are active. Therefore, we propose that H2A.X plays an important role in regulating ZGA genes and TEs to establish totipotency.

Indexed as

DNA Transposable ElementsAnimalsEmbryo, MammalianHistonesHumansDNA Transposable ElementsH2AX protein, humanHistonesDuxH2A.XHistone variantTransposable elementZygotic genome activation

Identifiers

PMID34393157
PMCPMC8568613
OpenAlexW3195597211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.