Evidence map›Paper›PMID 34393094›Full record

ReviewSeminars in fetal & neonatal medicine2021

Bedside and laboratory neuromonitoring in neonatal encephalopathy.

L Chalak, L Hellstrom-Westas, S Bonifacio, T Tsuchida, V Chock, M El-Dib, An N Massaro, A Garcia-Alix, Newborn Brain Society Guidelines and Publications

Abstract readReview
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Temperature dysregulation during therapeutic hypothermia predicts long-term outcome in neonates with HIE.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  13. Article
  14. Evolution of early cerebral NIRS in hypoxic ischaemic encephalopathy.Acta paediatrica (Oslo, Norway : 1992) · 2022
    Observational
  15. Expert consensus on grading management of electroencephalogram monitoring in neonates.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Article
  16. Review
  17. [Biomarkers and neuromonitoring for prognosis of development after perinatal brain damage].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L ChalakUniversity of Texas Southwestern Medical Center, Dallas, USA. Electronic address: Lina.chalak@utsouthwestern.edu.
L Hellstrom-WestasDepartment of Women's and Children's Health, Uppsala University, Division of Neonatology, Uppsala University Hospital, Sweden. Electronic address: lena.westas@kbh.uu.se.
S BonifacioDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine; 750 Welch Road, Suite 315, Palo Alto, CA, 94304, USA. Electronic address: soniab1@stanford.edu.
T TsuchidaDepartment of Neurology and Pediatrics, George Washington University School of Medicine and Health Sciences, Children's National Hospital Division of Neurophysiology, Epilepsy and Critical Care, 111 Michigan Ave NW, West Wing, 4th Floor, Washington DC, 20010-2970, USA. Electronic address: TTsuchid@childrensnational.org.
V ChockDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine; 750 Welch Road, Suite 315, Palo Alto, CA, 94304, USA. Electronic address: vchock@stanford.edu.
M El-DibDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, CWN#418, Boston, MA, 02115, USA. Electronic address: mel-dib@bwh.harvard.edu.
An N MassaroDepartment of Pediatrics, The George Washington University School of Medicine and Division of Neonatology, Children's National Hospital, Washington, USA. Electronic address: anguyenm@childrensnational.org.
A Garcia-AlixInstitut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain; University of Barcelona, Barcelona, Spain; NeNe Foundation, Madrid, Spain; Passeig de Sant Joan de Déu, 2, 08950, Esplugues de Llobregat, Barcelona, Spain. Electronic address: alfredoalix@gmail.com.
Newborn Brain Society Guidelines and Publications

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal EncephalopathyR01NS102617 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LINA F CHALAK · 2017 to 2026
$4.0M
NINDS NIH HHS R01 NS102617NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

Several bedside and laboratory neuromonitoring tools are currently used in neonatal encephalopathy (NE) to assess 1) brain function [amplitude-integrated electroencephalogram (aEEG) and EEG], 2) cerebral oxygenation delivery and consumption [near-infrared spectroscopy (NIRS)] and 3) blood and cerebrospinal fluid biomarkers. The aim of the review is to provide the role of neuromonitoring in understanding the development of brain injury in these newborns and better predict their long-term outcome. Simultaneous use of these monitoring modalities may improve our ability to provide meaningful prognostic information regarding ongoing treatments. Evidence will be summarized in this review for each of these modalities, by describing (1) the methods, (2) the clinical evidence in context of NE both before and with hypothermia, and (3) the research and future directions.

Indexed as

Asphyxia NeonatorumHypothermia, InducedHypoxia-Ischemia, BrainBrainElectroencephalographyHumansInfant, NewbornSpectroscopy, Near-Infrared

Identifiers

PMID34393094
PMCPMC8627431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.