Evidence map›Paper›PMID 34393018›Full record

ArticleVaccine2021

Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination.

Daniel Grupel, Sivan Gazit, Licita Schreiber, Varda Nadler, Tamar Wolf, Rachel Lazar, Lia Supino-Rosin, Galit Perez, Asaf Peretz, Amir Ben Tov and 3 more

Abstract read
In one paragraph

Article in Vaccine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  14. SARS-CoV-2 spike IgG titres up to 137 days following Comirnaty mRNA COVID-19 vaccination, Israel, February to May 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
  15. Article
  16. Predictors of seroconversion after coronavirus disease 2019 vaccination.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Article
  17. Comparison of anti-SARS-CoV-2 IgG and IgA antibody responses post complete vaccination, 7 months later and after 3rd dose of the BNT162b2 vaccine in healthy adults.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Daniel GrupelBen-Gurion University, Beer Sheva, Israel. Electronic address: daniel@grupel.com.
Sivan GazitKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Israel.
Licita SchreiberMaccabi Healthcare Services, Central Laboratory, Rehovot, Israel.
Varda NadlerMaccabi Healthcare Services, Central Laboratory, Rehovot, Israel.
Tamar WolfMaccabi Healthcare Services, Central Laboratory, Rehovot, Israel.
Rachel LazarMaccabi Healthcare Services, Central Laboratory, Rehovot, Israel.
Lia Supino-RosinMaccabi Healthcare Services, Central Laboratory, Rehovot, Israel.
Galit PerezKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Israel.
Asaf PeretzInternal Medicine COVID-19 Ward, Samson Assuta Ashdod University Hospital, Ashdod, Israel.
Amir Ben TovKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Miri Mizrahi-ReuveniHealth Division, Maccabi Healthcare Services, Tel Aviv, Israel.
Gabriel ChodickSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Maccabitech Institute for Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.
Tal PatalonKahn Sagol Maccabi (KSM) Research & Innovation Center, Maccabi Healthcare Services, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.

Indexed as

COVID-19SARS-CoV-2BNT162 VaccineCOVID-19 VaccinesHumansImmunoglobulin GKineticsRetrospective StudiesVaccinationBNT162 VaccineCOVID-19 VaccinesImmunoglobulin GBNT162b2IgG kineticsSARS-CoV-2Serology

Identifiers

PMID34393018
PMCPMC8354802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.