SynthesisBosnian journal of basic medical sciences2022
COVID-19 associated cranial nerve neuropathy: A systematic review.
Synthesis in Bosnian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Brain MRI findings in neurologically symptomatic COVID-19 patients: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Probable cavernous sinus-adjacent meningeal metastasis from esophageal squamous cell carcinoma: A case report.Oncology letters · 2026Article
- Review
- Postinfectious polyneuritis cranialis: A case report.The Journal of international medical research · 2026Article
- Post-acute Corticospinal and Spinal Tractopathy after Coronavirus Disease 2019: A Novel Post-infectious Neurological Syndrome?Internal medicine (Tokyo, Japan) · 2026Article
- Frequency and Etiologies of Peripheral Type Cranial Neuropathy in the Neurology Inpatient Clinic.Noro psikiyatri arsivi · 2026Article
- Cranial neuropathy during severe acute respiratory syndrome coronavirus 2 infection: a case report.Journal of medical case reports · 2025Article
- Ophthalmic complications associated with COVID-19: a large US national database analysis.Eye (London, England) · 2025Article
- Tapia Syndrome Secondary to Hypoglossal Nerve Schwannoma: A Case Report on a Rare Medical Condition.Cureus · 2025Article
- Glossopharyngeal neuralgia after SARS-CoV-2 infection: A case report.Journal of clinical and experimental dentistry · 2025Review
- Double-seropositive Myasthenia Gravis Following COVID-19.Internal medicine (Tokyo, Japan) · 2025Article
- COVID-19-Related Diplopia and Its Treatment.Medicina (Kaunas, Lithuania) · 2025Review
- Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study.Frontiers in neurology · 2025Article
- Authors' response to the Letter to the Editor.Skeletal radiology · 2024Article
- [Radiological clinical profile of multiple cranial neuropathy and recurrence risk factors].Revista medica del Instituto Mexicano del Seguro Social · 2024Observational
- Isolated Sixth Nerve Palsy and COVID-19: A Recurrent Case in a 7-Month-Old Child and Analysis of Reported Cases.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2024Review
- Review
- Effect of temperature and air pressure on the incidence of Bell's palsy in Hangzhou: a distributed lag non-linear analysis.Scientific reports · 2023Article
- Neuroprotective Agents with Therapeutic Potential for COVID-19.Biomolecules · 2023Review
- Parainfectious Brown-Séquard syndrome associated with COVID-19.BMJ case reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of cranial nerves is being increasingly recognised in COVID-19. This review aims to summarize and discuss the recent advances concerning the clinical presentation, pathophysiology, diagnosis, treatment, and outcomes of SARS-CoV-2 associated cranial nerve mononeuropathies or polyneuropathies. Therefore, a systematic review of articles from PubMed and Google Scholar was conducted. Altogether 36 articles regarding SARS-CoV-2 associated neuropathy of cranial nerves describing 56 patients were retrieved. Out of these 56 patients, cranial nerves were compromised without the involvement of peripheral nerves in 32 of the patients, while Guillain-Barre syndrome (GBS) with cranial nerve involvement was described in 24 patients. A single cranial nerve was involved either unilaterally or bilaterally in 36 patients, while in 19 patients multiple cranial nerves were involved. Bilateral involvement was more prevalent in the GBS group (n=11) as compared to the cohort with isolated cranial nerve involvement (n=5). Treatment of cranial nerve neuropathy included steroids (n=18), intravenous immunoglobulins (IVIG) (n=18), acyclovir/valacyclovir (n=3), and plasma exchange (n=1). The outcome was classified as "complete recovery" in 21 patients and as "partial recovery" in 30 patients. One patient had a lethal outcome. In conclusion, any cranial nerve can be involved in COVID-19, but cranial nerves VII, VI, and III are the most frequently affected. The involvement of cranial nerves in COVID-19 may or may not be associated with GBS. In patients with cranial nerve involvement, COVID-19 infections are usually mild. Isolated cranial nerve palsy without GBS usually responds favorably to steroids. Cranial nerve involvement with GBS benefits from IVIG.
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