Evidence map›Paper›PMID 34392706›Full record

ArticleBioTechniques2021

Colonoscopy-based intramucosal transplantation of cancer cells for mouse modeling of colon cancer and lung metastasis.

Rizwan Ahmad, Balawant Kumar, Raju Lama Tamang, Wei Xu, Geoffrey A Talmon, Aaron M Mohs, Punita Dhawan, Amar B Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioTechniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rizwan AhmadDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-0331-6687
Balawant KumarDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-8187-3078
Raju Lama TamangDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-3177-563X
Wei XuDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Geoffrey A TalmonDepartment of Pathology, University of Nebraska Medical Center, Omaha, NE, USA.
Aaron M MohsDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Punita DhawanDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
Amar B SinghDepartment of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-1908-8594
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · USNebraska Medical Center · USRenji Hospital · CN

Funding

Nebraska Center for Nanomedicine- Pilot ProjectsP30GM127200 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID · 2018 to 2022
$5.7M
Chloroquine-based polymer particles as oral non-absorbable treatment of inflammatory bowel diseaseR01DK124095 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI OUPICKY, DAVID, SINGH, AMAR B · 2020 to 2023
$2.1M
Mastl, a novel therapeutic target in Colon CancerR21CA216746 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DHAWAN, PUNITA · 2018 to 2019
$358k
BLRD VA I01 BX002086BLRD VA I01 BX002761National Institute of Cancer R21 grant funding CA216746National Institute of Health DK124095NCI NIH HHS R21 CA216746NIDDK NIH HHS R01 DK124095NIGMS NIH HHS P30 GM127200VA-merit award BX002086, BX002761
6 · The paper itself

Abstract

The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding of tumor growth, progression and eventual metastasis in its natural microenvironment. In the currently used murine models of CRC metastasis, the metastasis occurs primarily in the liver, though lung metastasis accounts for a significant proportion of CRC metastasis. There is an urgent need for a murine model of CRC, which not only allows tumor progression in the colonic mucosa but also metastasis of the lung. The authors describe a minimally invasive murine model of colon cancer progression that may be ideal for a wide range of applications, including evaluating gene function, microenvironment, cancer metastasis and therapeutic translational research.

Indexed as

Colonic NeoplasmsLung NeoplasmsNeoplasm TransplantationAnimalsCell Line, TumorColonoscopyDisease Models, AnimalMiceTumor Microenvironmentcolon cancercolonoscopylung metastasismetastasisxenograft

Identifiers

PMID34392706
PMCPMC8867397
OpenAlexW3195767709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.